Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions
Shen, ZQ; Dong, ZJ; Cheng, P; Li, L; Chen, ZH; Liu, J
2003-07-01
Source PublicationPLANTA MEDICA
ISSN0032-0943
Volume69Issue:7Pages:605-609
AbstractThe effects of plumbagin were investigated on platelet aggregation in vitro and ex vivo, on the binding of thrombin-stimulated platelets to neutrophils, and platelet aggregation induced by intact neutrophils and N-formyt-methionyl-leucyl-phenylalanine (fMLP) or platelet activating factor (PAF) activated neutrophils, by use of the methods of Hamburger, McEver and Born, respectively. The results showed that plumbagin in vitro significantly inhibited adenosine diphosphate (ADP)-, arachidonic acid (AA)-, or platelet activating factor (PAF)-induced platelet aggregation, in a concentration-dependent manner. The medium inhibitory concentrations (IC50) were 39.4, 82.7 and 38.1 muM respectively. Intragastric plumbagin at 10 mg/kg markedly suppressed platelet aggregation induced by ADP, AA, or PAF. Plumbagin decreased the binding between thrombin-stimulated platelets and neutrophils with an IC50 of 62.9 muM. Plumbagin significantly inhibited washed platelet aggregation stimulated by fMLP- or PAF-activated neutrophils. The IC50 values were 54.3 and 47.6 muM, respectively. On the other hand, plumbagin and aspirin increased the inhibition of intact neutrophils on AA-induced platelet aggregation. It is suggested that plumbagin inhibited platelet aggregation in vitro and ex vivo, suppressed the binding of activated platelets to neutrophils, inhibited platelet aggregation induced by activated neutrophils, and increased inhibition of intact neutrophils on platelet reactivity.
KeywordPlumbagin Platelet Aggregation Platelet-neutrophil Interactions
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000184890000003
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/13621
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China
Recommended Citation
GB/T 7714
Shen, ZQ,Dong, ZJ,Cheng, P,et al. Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions[J]. PLANTA MEDICA,2003,69(7):605-609.
APA Shen, ZQ,Dong, ZJ,Cheng, P,Li, L,Chen, ZH,&Liu, J.(2003).Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions.PLANTA MEDICA,69(7),605-609.
MLA Shen, ZQ,et al."Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions".PLANTA MEDICA 69.7(2003):605-609.
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