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题名: Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions
作者: Shen, ZQ; Dong, ZJ; Cheng, P; Li, L; Chen, ZH; Liu, J
刊名: PLANTA MEDICA
关键词: plumbagin ; platelet aggregation ; platelet-neutrophil interactions
英文摘要: The effects of plumbagin were investigated on platelet aggregation in vitro and ex vivo, on the binding of thrombin-stimulated platelets to neutrophils, and platelet aggregation induced by intact neutrophils and N-formyt-methionyl-leucyl-phenylalanine (fMLP) or platelet activating factor (PAF) activated neutrophils, by use of the methods of Hamburger, McEver and Born, respectively. The results showed that plumbagin in vitro significantly inhibited adenosine diphosphate (ADP)-, arachidonic acid (AA)-, or platelet activating factor (PAF)-induced platelet aggregation, in a concentration-dependent manner. The medium inhibitory concentrations (IC50) were 39.4, 82.7 and 38.1 muM respectively. Intragastric plumbagin at 10 mg/kg markedly suppressed platelet aggregation induced by ADP, AA, or PAF. Plumbagin decreased the binding between thrombin-stimulated platelets and neutrophils with an IC50 of 62.9 muM. Plumbagin significantly inhibited washed platelet aggregation stimulated by fMLP- or PAF-activated neutrophils. The IC50 values were 54.3 and 47.6 muM, respectively. On the other hand, plumbagin and aspirin increased the inhibition of intact neutrophils on AA-induced platelet aggregation. It is suggested that plumbagin inhibited platelet aggregation in vitro and ex vivo, suppressed the binding of activated platelets to neutrophils, inhibited platelet aggregation induced by activated neutrophils, and increased inhibition of intact neutrophils on platelet reactivity.
出版日期: 2003-07-01
卷号: 69, 期号:7, 页码:605-609
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13621
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China

Recommended Citation:
Shen, ZQ; Dong, ZJ; Cheng, P; Li, L; Chen, ZH; Liu, J.Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions,PLANTA MEDICA,2003,69(7):605-609
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