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题名: Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea
作者: Yang, WM; Liu, JK; Qing, C; Liu, YD; Ding, ZH; Shen, ZQ; Chen, ZH
刊名: PLANTA MEDICA
关键词: albaconol ; Albatrellus confluens ; Polyporaceae ; capsazepine ; capsaicin ; vanilloid receptor ; guinea pig trachea ; contraction
英文摘要: The contraction and desensitization induced by albaconol and the influence of capsazepine, capsaicin and extracellular Ca2+ were investigated to see whether the actions were mediated via a specific VR receptor in guinea pig trachea spiral strips in vitro.. Both albaconol and capsaicin were contractors of tracheal smooth muscle, but albaconol was not so potent as capsaicin, with -log (M) EC50 values of 4.23 +/- 0.18 (n = 10) and 7.33 +/- 0.21 (n = 10) respectively. 2.5 muM capsazepine competitively antagonized the contractile response to albaconol and capsaicin. Albaconol increased the contraction induced by a low dose of capsaicin (10(-10) to 10(-9) M), but non-competitively antagonized the contraction induced by a high dose of capsaicin (10(-8) to 10(-3) M). Either albaconol (1 or 100 mM) or capsaicin (3 or 10 muM) was able to desensitize the isolated guinea pig bronchi to subsequent addition of albaconol. Capsazepine (5.0 muM) significantly prevented the desensitization induced by either albaconol (1 or 100 mM) or capsaicin (3 or 10 muM). Extracellular Ca2+ was essential for albaconol to induce excitation, but it did not affect albaconol- or capsaicin-induced desensitization. In summary, the results from the present study suggest that albaconol induces contraction and desensitization of guinea pig trachea in vitro as a partial agonist for VR.
出版日期: 2003-08-01
卷号: 69, 期号:8, 页码:715-719
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13619
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China
3.Kunming Pharmacol Co, Drug Res & Dev Dept, Kunming, Peoples R China

Recommended Citation:
Yang, WM; Liu, JK; Qing, C; Liu, YD; Ding, ZH; Shen, ZQ; Chen, ZH.Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea,PLANTA MEDICA,2003,69(8):715-719
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文件名: PLANTA MEDICA69 715-719.pdf
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