Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea
Yang, WM; Liu, JK; Qing, C; Liu, YD; Ding, ZH; Shen, ZQ; Chen, ZH
2003-08-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号69期号:8页码:715-719
摘要The contraction and desensitization induced by albaconol and the influence of capsazepine, capsaicin and extracellular Ca2+ were investigated to see whether the actions were mediated via a specific VR receptor in guinea pig trachea spiral strips in vitro.. Both albaconol and capsaicin were contractors of tracheal smooth muscle, but albaconol was not so potent as capsaicin, with -log (M) EC50 values of 4.23 +/- 0.18 (n = 10) and 7.33 +/- 0.21 (n = 10) respectively. 2.5 muM capsazepine competitively antagonized the contractile response to albaconol and capsaicin. Albaconol increased the contraction induced by a low dose of capsaicin (10(-10) to 10(-9) M), but non-competitively antagonized the contraction induced by a high dose of capsaicin (10(-8) to 10(-3) M). Either albaconol (1 or 100 mM) or capsaicin (3 or 10 muM) was able to desensitize the isolated guinea pig bronchi to subsequent addition of albaconol. Capsazepine (5.0 muM) significantly prevented the desensitization induced by either albaconol (1 or 100 mM) or capsaicin (3 or 10 muM). Extracellular Ca2+ was essential for albaconol to induce excitation, but it did not affect albaconol- or capsaicin-induced desensitization. In summary, the results from the present study suggest that albaconol induces contraction and desensitization of guinea pig trachea in vitro as a partial agonist for VR.
关键词Albaconol Albatrellus Confluens Polyporaceae Capsazepine Capsaicin Vanilloid Receptor Guinea Pig Trachea Contraction
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13619
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China
3.Kunming Pharmacol Co, Drug Res & Dev Dept, Kunming, Peoples R China
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Yang, WM,Liu, JK,Qing, C,et al. Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea[J]. PLANTA MEDICA,2003,69(8):715-719.
APA Yang, WM.,Liu, JK.,Qing, C.,Liu, YD.,Ding, ZH.,...&Chen, ZH.(2003).Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea.PLANTA MEDICA,69(8),715-719.
MLA Yang, WM,et al."Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea".PLANTA MEDICA 69.8(2003):715-719.
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