Henrylactones A-E and Anti-HBV Constituents from Illicium henryi

doi:10.1055/s-0029-1186037

	Henrylactones A-E and Anti-HBV Constituents from Illicium henryi
	Liu, Ji-Feng 1,2; Jiang, Zhi-Yong 1; Zhang, Quan 1,2; Shi, Yao ; Ma, Yun-Bao 1; Xie, Ming-Jin 3; Zhang, Xue-Mei1 ; Chen, Ji-Jun1,2
	2010
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	76 期号:2 页码:152-158
摘要	Five new sesquiterpene lactones, henrylactones A-E (1-5), together with ten known compounds: cycloparvifloralone (6), tashironin (7), tashironin A (8), neoanisatin (9), anisatin (10), anislactone B (11), 7-O-acetylanislactone B (12), merrillianolide (13), cyclomerrillianolide (14) and pseudomajucin (15), were isolated from the stems and roots of Illicium henryi. Their structures were elucidated based on extensive spectroscopic data analyses. Among them, henrylactone A (1) is a novel sesquiterpene with a dilactone moiety and its structure was confirmed by X-ray diffraction. Sesquiterpene lactones 1-15 were tested for their anti-hepatitis B virus (HBV) activities. The most active compound, tashironin (7), exhibited an IC(50) value of 0.48 mM (SI = 6.3) inhibiting on HBV surface antigen (HBsAg) secretion and an IC(50) value of 0.15 mM(SI = 20.1) inhibiting on HBV e antigen (HBeAg) secretion using HBV transfected Hep G2.2.15 cell line.
关键词	Illiciaceae Illicium Henryi Sesquiterpene Lactone Henrylactones A-e Anti-hbv Activity
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1055/s-0029-1186037
收录类别	SCI
语种	英语
WOS记录号	WOS:000274261100009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/13587
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Yunnan Univ, Dept Chem, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ji-Feng,Jiang, Zhi-Yong,Zhang, Quan,et al. Henrylactones A-E and Anti-HBV Constituents from Illicium henryi[J]. PLANTA MEDICA,2010,76(2):152-158.
APA	Liu, Ji-Feng.,Jiang, Zhi-Yong.,Zhang, Quan.,Shi, Yao.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2010).Henrylactones A-E and Anti-HBV Constituents from Illicium henryi.PLANTA MEDICA,76(2),152-158.
MLA	Liu, Ji-Feng,et al."Henrylactones A-E and Anti-HBV Constituents from Illicium henryi".PLANTA MEDICA 76.2(2010):152-158.

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