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题名: Henrylactones A-E and Anti-HBV Constituents from Illicium henryi
作者: Liu, Ji-Feng1, 2; Jiang, Zhi-Yong1; Zhang, Quan1, 2; Shi, Yao; Ma, Yun-Bao1; Xie, Ming-Jin3; Zhang, Xue-Mei1; null(陈纪军)1, 2
刊名: PLANTA MEDICA
关键词: Illiciaceae ; Illicium henryi ; sesquiterpene lactone ; henrylactones A-E ; anti-HBV activity
英文摘要: Five new sesquiterpene lactones, henrylactones A-E (1-5), together with ten known compounds: cycloparvifloralone (6), tashironin (7), tashironin A (8), neoanisatin (9), anisatin (10), anislactone B (11), 7-O-acetylanislactone B (12), merrillianolide (13), cyclomerrillianolide (14) and pseudomajucin (15), were isolated from the stems and roots of Illicium henryi. Their structures were elucidated based on extensive spectroscopic data analyses. Among them, henrylactone A (1) is a novel sesquiterpene with a dilactone moiety and its structure was confirmed by X-ray diffraction. Sesquiterpene lactones 1-15 were tested for their anti-hepatitis B virus (HBV) activities. The most active compound, tashironin (7), exhibited an IC(50) value of 0.48 mM (SI = 6.3) inhibiting on HBV surface antigen (HBsAg) secretion and an IC(50) value of 0.15 mM(SI = 20.1) inhibiting on HBV e antigen (HBeAg) secretion using HBV transfected Hep G2.2.15 cell line.
出版日期: 2010
卷号: 76, 期号:2, 页码:152-158
DOI标识: 10.1055/s-0029-1186037
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13587
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Yunnan Univ, Dept Chem, Kunming, Yunnan, Peoples R China

Recommended Citation:
Liu, JF; Jiang, ZY; Zhang, Q; Shi, Y; Ma, YB; Xie, MJ; Zhang, XM; Chen, JJ.Henrylactones A-E and Anti-HBV Constituents from Illicium henryi,PLANTA MEDICA,2010,76(2):152-158
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