Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27
Yan, Jian; Sun, Lirong; Li, Wei; Zhou, Lin; Li, Zhongrong; Zhang, Xianmin; Yang, Ling; Qiu, Minghua1
2010-03-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号76期号:4页码:353-357
摘要Four serratane-type triterpenes (1-4) were isolated from D. complanatum. Their chemical structures were elucidated as 14 alpha, 15 alpha, 20 beta, 21 beta, 24, 27 alpha,29-heptahydroxyserrat-3-one (1), 3 beta, 14 alpha, 15 alpha,20 beta,21 beta,24,27 alpha, 29-octahydroxyserratane (2), 3 alpha,14 alpha,20 beta,21 beta,24,27 beta, 29-heptahydroxyserratane (3) and 3 beta,14 alpha,21 beta,24,27 beta-pentahydroxylserratane-29-yl (E)-p-coumarate (4) by spectroscopic methods (MS, 1D and 2D NMR) and X-ray crystallography. Interestingly, the most characteristic methylene (C-27) of the serratane ring C was oxidized to a methine. Compound 4 showed significant cytotoxic activity against the human leukemia K562/S and the doxorubicin-resistant K562/R cell lines, but the other compounds were inactive.
关键词Lycopodiaceae Diphasiastrum Complanatum Serratane-type Complanatumols A-d Leukemia
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-0029-1186168
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000275033200008
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13581
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, S China Bot Garden, Guangzhou, Guangdong, Peoples R China
3.So Med Univ, Sch Basic Med Sci, Guangzhou, Guangdong, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resources Discovery, Dalian, Peoples R China
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Yan, Jian,Sun, Lirong,Li, Wei,et al. Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27[J]. PLANTA MEDICA,2010,76(4):353-357.
APA Yan, Jian.,Sun, Lirong.,Li, Wei.,Zhou, Lin.,Li, Zhongrong.,...&Qiu, Minghua.(2010).Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27.PLANTA MEDICA,76(4),353-357.
MLA Yan, Jian,et al."Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27".PLANTA MEDICA 76.4(2010):353-357.
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