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题名: Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27
作者: Yan, Jian; Sun, Lirong; Li, Wei; Zhou, Lin; Li, Zhongrong; Zhang, Xianmin; Yang, Ling; null(邱明华)1
刊名: PLANTA MEDICA
关键词: Lycopodiaceae ; Diphasiastrum complanatum ; serratane-type ; complanatumols A-D ; leukemia
英文摘要: Four serratane-type triterpenes (1-4) were isolated from D. complanatum. Their chemical structures were elucidated as 14 alpha, 15 alpha, 20 beta, 21 beta, 24, 27 alpha,29-heptahydroxyserrat-3-one (1), 3 beta, 14 alpha, 15 alpha,20 beta,21 beta,24,27 alpha, 29-octahydroxyserratane (2), 3 alpha,14 alpha,20 beta,21 beta,24,27 beta, 29-heptahydroxyserratane (3) and 3 beta,14 alpha,21 beta,24,27 beta-pentahydroxylserratane-29-yl (E)-p-coumarate (4) by spectroscopic methods (MS, 1D and 2D NMR) and X-ray crystallography. Interestingly, the most characteristic methylene (C-27) of the serratane ring C was oxidized to a methine. Compound 4 showed significant cytotoxic activity against the human leukemia K562/S and the doxorubicin-resistant K562/R cell lines, but the other compounds were inactive.
出版日期: 2010-03-01
卷号: 76, 期号:4, 页码:353-357
DOI标识: 10.1055/s-0029-1186168
语种: 英语
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13581
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, S China Bot Garden, Guangzhou, Guangdong, Peoples R China
3.So Med Univ, Sch Basic Med Sci, Guangzhou, Guangdong, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resources Discovery, Dalian, Peoples R China

Recommended Citation:
Yan, J; Sun, LR; Li, W; Zhou, L; Li, ZR; Zhang, XM; Yang, L; Qiu, MH.Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27,PLANTA MEDICA,2010,76(4):353-357
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