Neoclerodane Diterpenoids from Scutellaria barbata
Zhu, Feng1,2; Di, Ying-Tong1; Li, Xing-Yao1; Liu, Ling-Li1; Zhang, Qiang1; Li, Yan1; Hao, Xiao-Jiang1; He, Hong-Ping1
2011-09-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号77期号:13页码:1536-1541
摘要Eight new neoclerodane diterpenoids (1-8), scutebatas H-O, together with eight known compounds, have been isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 was evaluated. Compounds 5, 6, 7 showed moderate cytotoxicities against several human cancer cell lines, with IC(50) values ranging from 12.6-31.4 mu M. In addition, compound 1 showed selective cytotoxicity against MCF-7.
关键词Scutellaria Barbata Lamiaceae Neoclerodane Diterpenoids Scutebatas H-o Cytotoxicity
资助信息Ministry of Science and Technology of China[2009CB940900, 2009CB522300]; Foundation of the Chinese Academy of Sciences; Young Academic and Technical Leader Raising Foundation of Yunnan Province[2010CI047]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1055/s-0030-1270797
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000294481300013
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13577
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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Zhu, Feng,Di, Ying-Tong,Li, Xing-Yao,et al. Neoclerodane Diterpenoids from Scutellaria barbata[J]. PLANTA MEDICA,2011,77(13):1536-1541.
APA Zhu, Feng.,Di, Ying-Tong.,Li, Xing-Yao.,Liu, Ling-Li.,Zhang, Qiang.,...&He, Hong-Ping.(2011).Neoclerodane Diterpenoids from Scutellaria barbata.PLANTA MEDICA,77(13),1536-1541.
MLA Zhu, Feng,et al."Neoclerodane Diterpenoids from Scutellaria barbata".PLANTA MEDICA 77.13(2011):1536-1541.
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