Antiproliferative Diterpenoids from the Leaves of Isodon rubescens
Gao, Xue-Mei1,4; Luo, Xiao1; Pu, Jian-Xin1; Wu, Ying-Li2,3; Zhao, Yong1; Yang, Li Bin1; He, Fei1; Li, Xiao Nian1; Xiao, Wei-Lie1; Chen, Guo-Qiang2,3; Sun, Han-Dong1
Corresponding AuthorSun, HD (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Lan Hei Rd, Kunming 650204, Yunnan, Peoples R China
2011
Source PublicationPLANTA MEDICA
ISSN0032-0943
Volume77Issue:2Pages:169-174
AbstractA phytochemical study of Isodon rubescens leaves led to the isolation of five new diterpenoids, isorubesins A-E (1 - 5), and fifteen known diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence. Most of the diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells. Some of them showed potent inhibitory activity. Compound 5 is the first reported atisane-type diterpenoid from this plant.
KeywordIsodon Rubescens Labiatae Cytotoxicity Diterpenoid
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
DOI10.1055/s-0030-1250165
Indexed BySCI
Language英语
WOS IDWOS:000286461000012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/13575
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Dept Pathophysiol, Shanghai 200030, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Key Lab Cell Differentiat & Apoptosis, Chinese Minist Educ, Shanghai 200030, Peoples R China
4.Yunnan Nationalities Univ, Sch Chem & Biotechnol, Kunming 650031, Peoples R China
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Gao, Xue-Mei,Luo, Xiao,Pu, Jian-Xin,et al. Antiproliferative Diterpenoids from the Leaves of Isodon rubescens[J]. PLANTA MEDICA,2011,77(2):169-174.
APA Gao, Xue-Mei.,Luo, Xiao.,Pu, Jian-Xin.,Wu, Ying-Li.,Zhao, Yong.,...&Sun, Han-Dong.(2011).Antiproliferative Diterpenoids from the Leaves of Isodon rubescens.PLANTA MEDICA,77(2),169-174.
MLA Gao, Xue-Mei,et al."Antiproliferative Diterpenoids from the Leaves of Isodon rubescens".PLANTA MEDICA 77.2(2011):169-174.
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