Antiproliferative Diterpenoids from the Leaves of Isodon rubescens
Gao, Xue-Mei1,4; Luo, Xiao1; Pu, Jian-Xin1; Wu, Ying-Li2,3; Zhao, Yong1; Yang, Li Bin1; He, Fei1; Li, Xiao Nian1; Xiao, Wei-Lie1; Chen, Guo-Qiang2,3; Sun, Han-Dong1
2011
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号77期号:2页码:169-174
摘要A phytochemical study of Isodon rubescens leaves led to the isolation of five new diterpenoids, isorubesins A-E (1 - 5), and fifteen known diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence. Most of the diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells. Some of them showed potent inhibitory activity. Compound 5 is the first reported atisane-type diterpenoid from this plant.
关键词Isodon Rubescens Labiatae Cytotoxicity Diterpenoid
资助信息NSFC[30772637]; NSFC-Joint Foundation of Yunnan Province[U0832602]; Major State Basic Research Development Program of China[2009CB522300]; Natural Science Foundation of Yunnan Province[2008CD162]; CAS[KSCX2-YW-R-097]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1055/s-0030-1250165
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000286461000012
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13575
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Dept Pathophysiol, Shanghai 200030, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Key Lab Cell Differentiat & Apoptosis, Chinese Minist Educ, Shanghai 200030, Peoples R China
4.Yunnan Nationalities Univ, Sch Chem & Biotechnol, Kunming 650031, Peoples R China
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Gao, Xue-Mei,Luo, Xiao,Pu, Jian-Xin,et al. Antiproliferative Diterpenoids from the Leaves of Isodon rubescens[J]. PLANTA MEDICA,2011,77(2):169-174.
APA Gao, Xue-Mei.,Luo, Xiao.,Pu, Jian-Xin.,Wu, Ying-Li.,Zhao, Yong.,...&Sun, Han-Dong.(2011).Antiproliferative Diterpenoids from the Leaves of Isodon rubescens.PLANTA MEDICA,77(2),169-174.
MLA Gao, Xue-Mei,et al."Antiproliferative Diterpenoids from the Leaves of Isodon rubescens".PLANTA MEDICA 77.2(2011):169-174.
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