Cytotoxic Steroids from Sarcococca saligna

doi:10.1055/s-0030-1271101

	Cytotoxic Steroids from Sarcococca saligna
	Yan, Yu-Xin 1,2; Sun, Yun 1,2; Chen, Jian-Chao 1; Wang, Yuan-Yuan 1; Li, Yan1 ; Qiu, Ming-Hua1
通讯作者	Qiu, MH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, 134 Lan Hei Rd, Kunming 650204, Peoples R China
	2011-10-01
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	77 期号:15 页码:1725-1729
摘要	Two new C(21)-steroidal esters, sarsaligates A (1) and B (2), and two new steroidal alkaloids, sarsaligenines A (3) and B (4), together with four known compounds (sarcovagine, sarcorucinine, dimethylamino-3 beta-pregnane-20-one, and beta-sitosterol 5-8, respectively), were isolated from the leaves and stems of Sarcococca saligna. The structures of compounds 1-4 were elucidated by NMR and MS spectroscopic analysis. Of the compounds tested, 5 and 6 were the most cytotoxic against the cell lines K562, SK-BR-3, and PANC-1, with IC50 values in the range of 2.25-5.00 mu M, while 3 and 4 selectively inhibited HL-60 cells with IC(50) values of 2.87 and 3.61 mu M, respectively. Compounds 3-6 therefore deserve further evaluation of their cytotoxic potentials.
关键词	Buxaceae Sarcococca Saligna Sarsaligates A/b Sarsaligenines A/b Cytotoxicity
学科领域	Plant Sciences ; Pharmacology & Pharmacy
DOI	10.1055/s-0030-1271101
收录类别	SCI
语种	英语
WOS记录号	WOS:000296188000010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/13573
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yan, Yu-Xin,Sun, Yun,Chen, Jian-Chao,et al. Cytotoxic Steroids from Sarcococca saligna[J]. PLANTA MEDICA,2011,77(15):1725-1729.
APA	Yan, Yu-Xin,Sun, Yun,Chen, Jian-Chao,Wang, Yuan-Yuan,Li, Yan,&Qiu, Ming-Hua.(2011).Cytotoxic Steroids from Sarcococca saligna.PLANTA MEDICA,77(15),1725-1729.
MLA	Yan, Yu-Xin,et al."Cytotoxic Steroids from Sarcococca saligna".PLANTA MEDICA 77.15(2011):1725-1729.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
PLANTA MEDICA77 1725（8802KB）			开放获取	--	浏览下载