Cytotoxic Steroids from Sarcococca saligna
Yan, Yu-Xin1,2; Sun, Yun1,2; Chen, Jian-Chao1; Wang, Yuan-Yuan1; Li, Yan1; Qiu, Ming-Hua1
2011-10-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号77期号:15页码:1725-1729
摘要Two new C(21)-steroidal esters, sarsaligates A (1) and B (2), and two new steroidal alkaloids, sarsaligenines A (3) and B (4), together with four known compounds (sarcovagine, sarcorucinine, dimethylamino-3 beta-pregnane-20-one, and beta-sitosterol 5-8, respectively), were isolated from the leaves and stems of Sarcococca saligna. The structures of compounds 1-4 were elucidated by NMR and MS spectroscopic analysis. Of the compounds tested, 5 and 6 were the most cytotoxic against the cell lines K562, SK-BR-3, and PANC-1, with IC50 values in the range of 2.25-5.00 mu M, while 3 and 4 selectively inhibited HL-60 cells with IC(50) values of 2.87 and 3.61 mu M, respectively. Compounds 3-6 therefore deserve further evaluation of their cytotoxic potentials.
关键词Buxaceae Sarcococca Saligna Sarsaligates A/b Sarsaligenines A/b Cytotoxicity
资助信息CAS[KSCX2-YW-G-038, 027, KSCX2-YW-R-194, 29, KZCX2-XB2-15-03]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2008-ZZ05, P2010-ZZ14]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1055/s-0030-1271101
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000296188000010
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13573
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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Yan, Yu-Xin,Sun, Yun,Chen, Jian-Chao,et al. Cytotoxic Steroids from Sarcococca saligna[J]. PLANTA MEDICA,2011,77(15):1725-1729.
APA Yan, Yu-Xin,Sun, Yun,Chen, Jian-Chao,Wang, Yuan-Yuan,Li, Yan,&Qiu, Ming-Hua.(2011).Cytotoxic Steroids from Sarcococca saligna.PLANTA MEDICA,77(15),1725-1729.
MLA Yan, Yu-Xin,et al."Cytotoxic Steroids from Sarcococca saligna".PLANTA MEDICA 77.15(2011):1725-1729.
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