Cytotoxic Steroids from Sarcococca saligna
Yan, Yu-Xin1,2; Sun, Yun1,2; Chen, Jian-Chao1; Wang, Yuan-Yuan1; Li, Yan1; Qiu, Ming-Hua1
Corresponding AuthorQiu, MH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, 134 Lan Hei Rd, Kunming 650204, Peoples R China
Source PublicationPLANTA MEDICA
AbstractTwo new C(21)-steroidal esters, sarsaligates A (1) and B (2), and two new steroidal alkaloids, sarsaligenines A (3) and B (4), together with four known compounds (sarcovagine, sarcorucinine, dimethylamino-3 beta-pregnane-20-one, and beta-sitosterol 5-8, respectively), were isolated from the leaves and stems of Sarcococca saligna. The structures of compounds 1-4 were elucidated by NMR and MS spectroscopic analysis. Of the compounds tested, 5 and 6 were the most cytotoxic against the cell lines K562, SK-BR-3, and PANC-1, with IC50 values in the range of 2.25-5.00 mu M, while 3 and 4 selectively inhibited HL-60 cells with IC(50) values of 2.87 and 3.61 mu M, respectively. Compounds 3-6 therefore deserve further evaluation of their cytotoxic potentials.
KeywordBuxaceae Sarcococca Saligna Sarsaligates A/b Sarsaligenines A/b Cytotoxicity
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Indexed BySCI
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000296188000010
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Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yan, Yu-Xin,Sun, Yun,Chen, Jian-Chao,et al. Cytotoxic Steroids from Sarcococca saligna[J]. PLANTA MEDICA,2011,77(15):1725-1729.
APA Yan, Yu-Xin,Sun, Yun,Chen, Jian-Chao,Wang, Yuan-Yuan,Li, Yan,&Qiu, Ming-Hua.(2011).Cytotoxic Steroids from Sarcococca saligna.PLANTA MEDICA,77(15),1725-1729.
MLA Yan, Yu-Xin,et al."Cytotoxic Steroids from Sarcococca saligna".PLANTA MEDICA 77.15(2011):1725-1729.
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