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题名: Cytotoxic Steroids from Sarcococca saligna
作者: Yan, Yu-Xin1, 2; Sun, Yun1, 2; Chen, Jian-Chao1; Wang, Yuan-Yuan1; null(李艳)1; null(邱明华)1
刊名: PLANTA MEDICA
关键词: Buxaceae ; Sarcococca saligna ; sarsaligates A/B ; sarsaligenines A/B ; cytotoxicity
英文摘要: Two new C(21)-steroidal esters, sarsaligates A (1) and B (2), and two new steroidal alkaloids, sarsaligenines A (3) and B (4), together with four known compounds (sarcovagine, sarcorucinine, dimethylamino-3 beta-pregnane-20-one, and beta-sitosterol 5-8, respectively), were isolated from the leaves and stems of Sarcococca saligna. The structures of compounds 1-4 were elucidated by NMR and MS spectroscopic analysis. Of the compounds tested, 5 and 6 were the most cytotoxic against the cell lines K562, SK-BR-3, and PANC-1, with IC50 values in the range of 2.25-5.00 mu M, while 3 and 4 selectively inhibited HL-60 cells with IC(50) values of 2.87 and 3.61 mu M, respectively. Compounds 3-6 therefore deserve further evaluation of their cytotoxic potentials.
出版日期: 2011-10-01
卷号: 77, 期号:15, 页码:1725-1729
DOI标识: 10.1055/s-0030-1271101
语种: 英语
ISSN号: 0032-0943
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13573
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Yan, YX; Sun, Y; Chen, JC; Wang, YY; Li, Y; Qiu, MH.Cytotoxic Steroids from Sarcococca saligna,PLANTA MEDICA,2011,77(15):1725-1729
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