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题名: Antimicrobial, Cytotoxic Lignans and Terpenoids from the Twigs of Pseudolarix kaempferi
作者: He, Wen-Jun1, 2; Chu, Hong-Biao1; Zhang, Yu-Mei1; Han, Hong-Jin1; Yan, He1, 2; Zeng, Guang-Zhi1; Fu, Zhao-Hui1; Olubanke, Ogunlana3; Tan, Ning-Hua1
刊名: PLANTA MEDICA
关键词: Pseudolarix kaempferi ; Pinaceae ; lignans ; terpenoids ; antimicrobial ; cytotoxic
英文摘要: Seven new compounds, including four lignans, (+)-(8S, 8'S)-9,9'-dibenzoylsecoisolariciresinol (1), (+)-(8S*, 8'R*)-4,4'-dimethyloxomatairesinol (2), (+)-(7S*, 8R*, 8'R*, 9'S*)-9'-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6), and a triterpene, 25-epi-pseudolarolide Q (7), along with 25 known compounds (8-32) were isolated from the twigs of Pseudolarix kaempferi. Their structures were elucidated mainly by the analysis of their NMR and MS data. Pseudolarolide C acid (24) was isolated for the first time as a natural product. All compounds were evaluated for antimicrobial activity against Candida albicans and Staphylococcus aureus, and cytotoxic activity against K562, HT29, B16, BGC-823, BEL-7402, SGC-7901, U251, and A549 cancer cell lines were assayed. Results indicated that the new compounds 3, 7, and some known compounds showed antimicrobial and cytotoxic activities.
出版日期: 2011-11-01
卷号: 77, 期号:17, 页码:1924-1931
DOI标识: 10.1055/s-0031-1280020
语种: 英语
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13567
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Covenant Univ, Dept Biol Sci, Coll Sci & Technol, Ota, Ogun State, Nigeria

Recommended Citation:
He, WJ; Chu, HB; Zhang, YM; Han, HJ; Yan, H; Zeng, GZ; Fu, ZH; Olubanke, O; Tan, NH.Antimicrobial, Cytotoxic Lignans and Terpenoids from the Twigs of Pseudolarix kaempferi,PLANTA MEDICA,2011,77(17):1924-1931
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