Antimicrobial, Cytotoxic Lignans and Terpenoids from the Twigs of Pseudolarix kaempferi
He, Wen-Jun1,2; Chu, Hong-Biao1; Zhang, Yu-Mei1; Han, Hong-Jin1; Yan, He1,2; Zeng, Guang-Zhi1; Fu, Zhao-Hui1; Olubanke, Ogunlana3; Tan, Ning-Hua1
通讯作者Tan, NH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2011-11-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号77期号:17页码:1924-1931
摘要Seven new compounds, including four lignans, (+)-(8S, 8'S)-9,9'-dibenzoylsecoisolariciresinol (1), (+)-(8S*, 8'R*)-4,4'-dimethyloxomatairesinol (2), (+)-(7S*, 8R*, 8'R*, 9'S*)-9'-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6), and a triterpene, 25-epi-pseudolarolide Q (7), along with 25 known compounds (8-32) were isolated from the twigs of Pseudolarix kaempferi. Their structures were elucidated mainly by the analysis of their NMR and MS data. Pseudolarolide C acid (24) was isolated for the first time as a natural product. All compounds were evaluated for antimicrobial activity against Candida albicans and Staphylococcus aureus, and cytotoxic activity against K562, HT29, B16, BGC-823, BEL-7402, SGC-7901, U251, and A549 cancer cell lines were assayed. Results indicated that the new compounds 3, 7, and some known compounds showed antimicrobial and cytotoxic activities.
关键词Pseudolarix Kaempferi Pinaceae Lignans Terpenoids Antimicrobial Cytotoxic
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1055/s-0031-1280020
收录类别SCI
语种英语
WOS记录号WOS:000298851200010
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13567
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Covenant Univ, Dept Biol Sci, Coll Sci & Technol, Ota, Ogun State, Nigeria
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He, Wen-Jun,Chu, Hong-Biao,Zhang, Yu-Mei,et al. Antimicrobial, Cytotoxic Lignans and Terpenoids from the Twigs of Pseudolarix kaempferi[J]. PLANTA MEDICA,2011,77(17):1924-1931.
APA He, Wen-Jun.,Chu, Hong-Biao.,Zhang, Yu-Mei.,Han, Hong-Jin.,Yan, He.,...&Tan, Ning-Hua.(2011).Antimicrobial, Cytotoxic Lignans and Terpenoids from the Twigs of Pseudolarix kaempferi.PLANTA MEDICA,77(17),1924-1931.
MLA He, Wen-Jun,et al."Antimicrobial, Cytotoxic Lignans and Terpenoids from the Twigs of Pseudolarix kaempferi".PLANTA MEDICA 77.17(2011):1924-1931.
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