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题名: New Chalcone and Dimeric Chalcones with 1,4-p-Benzoquinone Residue from Combretum yunnanense
作者: Wu, Ming-Mei1, 2; Wang, Li-Qin1; Hua, Yan2; Chen, Ye-Gao1; Wang, Yuan-Yuan3; Li, Xing-Yao3; null(李艳)3; Li, Ting1; Yang, Xun-Yun1; Tang, Zheng-Rong1
刊名: PLANTA MEDICA
关键词: Combretum yunnanense ; Combretaceae ; combrequinone A ; combrequinone B ; combrequinone C ; cytotoxicity
英文摘要: New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue, combrequinone A (1), combrequinone B (2), and combrequinone C (3), along with three known compounds (4-6), were isolated from the ethanolic extract of the stems and leaves of Combretum yunnanense, and their structures were determined by spectroscopic analysis. Compounds 1-3 were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, and SW480. Compounds 1, 2, and 3 were found to be most potent against HL-60 acute leukemia cells, with IC(50) values of 4.63, 4.07, and 1.26 mu M, respectively.
出版日期: 2011-03-01
卷号: 77, 期号:5, 页码:481-484
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13565
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Normal Univ, Dept Chem & Chem Engn, Kunming 650051, Yunnan, Peoples R China
2.SW Forestry Univ, Dept Nat Sources, Kunming, Yunnan, Peoples R China
3.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Drug Screening Ctr, Kunming, Peoples R China

Recommended Citation:
Wu, MM; Wang, LQ; Hua, Y; Chen, YG; Wang, YY; Li, XY; Li, Y; Li, T; Yang, XY; Tang, ZR.New Chalcone and Dimeric Chalcones with 1,4-p-Benzoquinone Residue from Combretum yunnanense,PLANTA MEDICA,2011,77(5):481-484
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