New Chalcone and Dimeric Chalcones with 1,4-p-Benzoquinone Residue from Combretum yunnanense
Wu, Ming-Mei1,2; Wang, Li-Qin1; Hua, Yan2; Chen, Ye-Gao1; Wang, Yuan-Yuan3; Li, Xing-Yao3; Li, Yan3; Li, Ting1; Yang, Xun-Yun1; Tang, Zheng-Rong1
2011-03-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号77期号:5页码:481-484
摘要New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue, combrequinone A (1), combrequinone B (2), and combrequinone C (3), along with three known compounds (4-6), were isolated from the ethanolic extract of the stems and leaves of Combretum yunnanense, and their structures were determined by spectroscopic analysis. Compounds 1-3 were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, and SW480. Compounds 1, 2, and 3 were found to be most potent against HL-60 acute leukemia cells, with IC(50) values of 4.63, 4.07, and 1.26 mu M, respectively.
关键词Combretum Yunnanense Combretaceae Combrequinone a Combrequinone b Combrequinone c Cytotoxicity
资助信息National Natural Science Foundations of China[20802064]; Natural Science Foundations of Yunnan Province[2007B200 M]
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13565
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Normal Univ, Dept Chem & Chem Engn, Kunming 650051, Yunnan, Peoples R China
2.SW Forestry Univ, Dept Nat Sources, Kunming, Yunnan, Peoples R China
3.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Drug Screening Ctr, Kunming, Peoples R China
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Wu, Ming-Mei,Wang, Li-Qin,Hua, Yan,et al. New Chalcone and Dimeric Chalcones with 1,4-p-Benzoquinone Residue from Combretum yunnanense[J]. PLANTA MEDICA,2011,77(5):481-484.
APA Wu, Ming-Mei.,Wang, Li-Qin.,Hua, Yan.,Chen, Ye-Gao.,Wang, Yuan-Yuan.,...&Tang, Zheng-Rong.(2011).New Chalcone and Dimeric Chalcones with 1,4-p-Benzoquinone Residue from Combretum yunnanense.PLANTA MEDICA,77(5),481-484.
MLA Wu, Ming-Mei,et al."New Chalcone and Dimeric Chalcones with 1,4-p-Benzoquinone Residue from Combretum yunnanense".PLANTA MEDICA 77.5(2011):481-484.
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