Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts
Lee, Yun Mi1; Kim, Young Sook1; Lee, Youngseop1; Kim, Junghyun1; Sun, Hang2; Kim, Joo Hwan3; Kim, Jin Sook1
Corresponding AuthorKim, JS (reprint author), KIOM, Diabet Complicat Res Ctr, Div Tradit Korean Med TKM Integrated Res, 483 Exporo, Taejon 305811, South Korea, jskim@kiom.re.kr
2012-05-01
Source PublicationPHYTOTHERAPY RESEARCH
ISSN0951-418X
Volume26Issue:5Pages:778-782
Abstract

To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants from Korea were screened for their antilipase activity for prevention of obesity. Dried and powdered plants were extracted three times with EtOH and extracts were obtained by removal of the solvent in vacuo. Lipase activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol. Also, the inhibitory effect was measured on phosphodiesterase (PDE), another therapeutic target for obesity. Of the extracts tested, Sorbus commixta (stem, leaf) and Viscum album (whole plant) exhibited antilipase activity (with IC50 values of 29.6?mu g/mL and 33.3?mu g/mL, respectively) and only anti-PDE activity (IC50 values of 20.08?mu g/mL and 35.15?mu g/mL, respectively). Copyright (c) 2011 John Wiley & Sons, Ltd.

KeywordPancreatic Lipase Phosphodiesterase Korean Medicinal Plants Sorbus Commixta Viscum Album
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1002/ptr.3644
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000302936700023
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/10475
Collection中国科学院东亚植物多样性与生物地理学重点实验室
Affiliation1.KIOM, Diabet Complicat Res Ctr, Div Tradit Korean Med TKM Integrated Res, Taejon 305811, South Korea
2.Chinese Acad Sci, Lab Biodivers & Biogeog, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
3.Kyungwon Univ, Dept Life Sci, Songnam 461701, Kyonggi Do, South Korea
Recommended Citation
GB/T 7714
Lee, Yun Mi,Kim, Young Sook,Lee, Youngseop,et al. Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts[J]. PHYTOTHERAPY RESEARCH,2012,26(5):778-782.
APA Lee, Yun Mi.,Kim, Young Sook.,Lee, Youngseop.,Kim, Junghyun.,Sun, Hang.,...&Kim, Jin Sook.(2012).Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts.PHYTOTHERAPY RESEARCH,26(5),778-782.
MLA Lee, Yun Mi,et al."Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts".PHYTOTHERAPY RESEARCH 26.5(2012):778-782.
Files in This Item: Download All
File Name/Size DocType Version Access License
Lee-2012-Inhibitory (127KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lee, Yun Mi]'s Articles
[Kim, Young Sook]'s Articles
[Lee, Youngseop]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lee, Yun Mi]'s Articles
[Kim, Young Sook]'s Articles
[Lee, Youngseop]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lee, Yun Mi]'s Articles
[Kim, Young Sook]'s Articles
[Lee, Youngseop]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Lee-2012-Inhibitory Activitie.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.