Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts
Lee, Yun Mi1; Kim, Young Sook1; Lee, Youngseop1; Kim, Junghyun1; Sun, Hang2; Kim, Joo Hwan3; Kim, Jin Sook1
2012-05-01
发表期刊PHYTOTHERAPY RESEARCH
ISSN0951-418X
卷号26期号:5页码:778-782
摘要To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants from Korea were screened for their antilipase activity for prevention of obesity. Dried and powdered plants were extracted three times with EtOH and extracts were obtained by removal of the solvent in vacuo. Lipase activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol. Also, the inhibitory effect was measured on phosphodiesterase (PDE), another therapeutic target for obesity. Of the extracts tested, Sorbus commixta (stem, leaf) and Viscum album (whole plant) exhibited antilipase activity (with IC50 values of 29.6?mu g/mL and 33.3?mu g/mL, respectively) and only anti-PDE activity (IC50 values of 20.08?mu g/mL and 35.15?mu g/mL, respectively). Copyright (c) 2011 John Wiley & Sons, Ltd.
关键词Pancreatic Lipase Phosphodiesterase Korean Medicinal Plants Sorbus Commixta Viscum Album
资助信息Korea Research Council of Fundamental Science and Technology (KRCF)[G10100]; Korea Institute of Oriental Medicine (KIOM)[K10040]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1002/ptr.3644
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000302936700023
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10475
专题中国科学院东亚植物多样性与生物地理学重点实验室
作者单位1.KIOM, Diabet Complicat Res Ctr, Div Tradit Korean Med TKM Integrated Res, Taejon 305811, South Korea
2.Chinese Acad Sci, Lab Biodivers & Biogeog, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
3.Kyungwon Univ, Dept Life Sci, Songnam 461701, Kyonggi Do, South Korea
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GB/T 7714
Lee, Yun Mi,Kim, Young Sook,Lee, Youngseop,et al. Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts[J]. PHYTOTHERAPY RESEARCH,2012,26(5):778-782.
APA Lee, Yun Mi.,Kim, Young Sook.,Lee, Youngseop.,Kim, Junghyun.,Sun, Hang.,...&Kim, Jin Sook.(2012).Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts.PHYTOTHERAPY RESEARCH,26(5),778-782.
MLA Lee, Yun Mi,et al."Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts".PHYTOTHERAPY RESEARCH 26.5(2012):778-782.
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