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题名: Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts
作者: Lee, Yun Mi1; Kim, Young Sook1; Lee, Youngseop1; Kim, Junghyun1; Sun Hang(孙航)2; Kim, Joo Hwan3; Kim, Jin Sook1
刊名: PHYTOTHERAPY RESEARCH
关键词: pancreatic lipase ; phosphodiesterase ; Korean medicinal plants ; Sorbus commixta ; Viscum album
英文摘要: To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants from Korea were screened for their antilipase activity for prevention of obesity. Dried and powdered plants were extracted three times with EtOH and extracts were obtained by removal of the solvent in vacuo. Lipase activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol. Also, the inhibitory effect was measured on phosphodiesterase (PDE), another therapeutic target for obesity. Of the extracts tested, Sorbus commixta (stem, leaf) and Viscum album (whole plant) exhibited antilipase activity (with IC50 values of 29.6?mu g/mL and 33.3?mu g/mL, respectively) and only anti-PDE activity (IC50 values of 20.08?mu g/mL and 35.15?mu g/mL, respectively). Copyright (c) 2011 John Wiley & Sons, Ltd.
出版日期: 2012-05-01
卷号: 26, 期号:5, 页码:778-782
DOI标识: 10.1002/ptr.3644
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0951-418X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10475
Appears in Collections:中国科学院东亚植物多样性与生物地理学重点实验室_期刊论文

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作者单位: 1.KIOM, Diabet Complicat Res Ctr, Div Tradit Korean Med TKM Integrated Res, Taejon 305811, South Korea
2.Chinese Acad Sci, Lab Biodivers & Biogeog, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
3.Kyungwon Univ, Dept Life Sci, Songnam 461701, Kyonggi Do, South Korea

Recommended Citation:
Lee, YM; Kim, YS; Lee, Y; Kim, J; Sun, H; Kim, JH; Kim, JS.Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts,PHYTOTHERAPY RESEARCH,2012,26(5):778-782
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