中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole
作者: Yang, Xiao-Dong1; Wan, Wei-Chao1; Deng, Xiao-Yan1; null(李艳)2; Yang, Li-Juan3, 4; Li, Liang1; Zhang, Hong-Bin1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Hybrid compound ; Benzofuran ; Imidazole ; Cytotoxic activities ; Structure-activity relationships
英文摘要: A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or bromophenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 15 was found to be the most potent compound against 4 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activity selectively against liver carcinoma (SMMC-7721). (C) 2012 Elsevier Ltd. All rights reserved.
出版日期: 2012-04-15
卷号: 22, 期号:8, 页码:2726-2729
DOI标识: 10.1016/j.bmcl.2012.02.094
语种: 英语
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10451
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Yang-2012-Design, synthesis an.pdf(283KB)----开放获取--View Download

作者单位: 1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China
4.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China

Recommended Citation:
Yang, XD; Wan, WC; Deng, XY; Li, Y; Yang, LJ; Li, L; Zhang, HB.Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(8):2726-2729
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Xiao-Dong]'s Articles
[Wan, Wei-Chao]'s Articles
[Deng, Xiao-Yan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Xiao-Dong]‘s Articles
[Wan, Wei-Chao]‘s Articles
[Deng, Xiao-Yan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Yang-2012-Design, synthesis an.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace