Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole
Yang, Xiao-Dong1; Wan, Wei-Chao1; Deng, Xiao-Yan1; Li, Yan2; Yang, Li-Juan3,4; Li, Liang1; Zhang, Hong-Bin1
2012-04-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号22期号:8页码:2726-2729
摘要A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or bromophenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 15 was found to be the most potent compound against 4 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activity selectively against liver carcinoma (SMMC-7721). (C) 2012 Elsevier Ltd. All rights reserved.
关键词Hybrid Compound Benzofuran Imidazole Cytotoxic Activities Structure-activity Relationships
资助信息National Natural Science Foundation of China[30960460, 21062026, 2010GA014, 2009CB522300]; Yunnan Province; National Basic Research Program of China (973 Program)
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10451
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China
4.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
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Yang, Xiao-Dong,Wan, Wei-Chao,Deng, Xiao-Yan,et al. Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(8):2726-2729.
APA Yang, Xiao-Dong.,Wan, Wei-Chao.,Deng, Xiao-Yan.,Li, Yan.,Yang, Li-Juan.,...&Zhang, Hong-Bin.(2012).Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(8),2726-2729.
MLA Yang, Xiao-Dong,et al."Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.8(2012):2726-2729.
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