| Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide | |
Xu, Junju1,2; Ji, Changjiu1; Zhang, Yumei1; Su, Jia1; Li, Yan1 ; Tan, Ninghua1
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| 通讯作者 | Tan, NH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China, nhtan@mail.kib.ac.cn |
| 2012-02-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| 卷号 | 22期号:4页码:1660-1663 |
| 摘要 | Sixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages, and their IC50 values ranged from 9.85 to 13.95 mu g/ml. (C) 2012 Elsevier Ltd. All rights reserved. |
| 关键词 | Zingiberaceae Alpinia Oxyphylla Sesquiterpenes Oxyphyllanene A-g Inhibitory Activity Against No Production |
| 学科领域 | Chemistry ; Organic ; Medicinal ; Chemistry |
| DOI | 10.1016/j.bmcl.2011.12.114 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300404900035 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/10449 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Junju,Ji, Changjiu,Zhang, Yumei,et al. Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(4):1660-1663. |
| APA | Xu, Junju,Ji, Changjiu,Zhang, Yumei,Su, Jia,Li, Yan,&Tan, Ninghua.(2012).Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(4),1660-1663. |
| MLA | Xu, Junju,et al."Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.4(2012):1660-1663. |
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