Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide
Xu, Junju1,2; Ji, Changjiu1; Zhang, Yumei1; Su, Jia1; Li, Yan1; Tan, Ninghua1
2012-02-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号22期号:4页码:1660-1663
摘要Sixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages, and their IC50 values ranged from 9.85 to 13.95 mu g/ml. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Zingiberaceae Alpinia Oxyphylla Sesquiterpenes Oxyphyllanene A-g Inhibitory Activity Against No Production
资助信息National Natural Science Foundation of China[30725048, 31000159, 91013002, U1032602]; National Basic Research Program of China[2009CB522300]; Chinese Academy of Sciences[KSCX2-YW-R-177]; National New Drug Innovation Major Project of China[2011ZX09307-002-002]
学科领域Chemistry ; Organic ; Medicinal ; Chemistry
DOI10.1016/j.bmcl.2011.12.114
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000300404900035
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10449
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China
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Xu, Junju,Ji, Changjiu,Zhang, Yumei,et al. Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(4):1660-1663.
APA Xu, Junju,Ji, Changjiu,Zhang, Yumei,Su, Jia,Li, Yan,&Tan, Ninghua.(2012).Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(4),1660-1663.
MLA Xu, Junju,et al."Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.4(2012):1660-1663.
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