Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide
Xu, Junju1,2; Ji, Changjiu1; Zhang, Yumei1; Su, Jia1; Li, Yan1; Tan, Ninghua1
Corresponding AuthorTan, NH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China, nhtan@mail.kib.ac.cn
2012-02-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume22Issue:4Pages:1660-1663
AbstractSixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages, and their IC50 values ranged from 9.85 to 13.95 mu g/ml. (C) 2012 Elsevier Ltd. All rights reserved.
KeywordZingiberaceae Alpinia Oxyphylla Sesquiterpenes Oxyphyllanene A-g Inhibitory Activity Against No Production
Subject AreaChemistry ; Organic ; Medicinal ; Chemistry
DOI10.1016/j.bmcl.2011.12.114
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000300404900035
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/10449
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Xu, Junju,Ji, Changjiu,Zhang, Yumei,et al. Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(4):1660-1663.
APA Xu, Junju,Ji, Changjiu,Zhang, Yumei,Su, Jia,Li, Yan,&Tan, Ninghua.(2012).Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(4),1660-1663.
MLA Xu, Junju,et al."Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.4(2012):1660-1663.
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