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题名: Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide
作者: Xu, Junju1, 2; Ji, Changjiu1; Zhang, Yumei1; Su, Jia1; null(李艳)1; Tan, Ninghua1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Zingiberaceae ; Alpinia oxyphylla ; Sesquiterpenes ; Oxyphyllanene A-G ; Inhibitory activity against NO production
英文摘要: Sixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages, and their IC50 values ranged from 9.85 to 13.95 mu g/ml. (C) 2012 Elsevier Ltd. All rights reserved.
出版日期: 2012-02-15
卷号: 22, 期号:4, 页码:1660-1663
DOI标识: 10.1016/j.bmcl.2011.12.114
语种: 英语
ISSN号: 0960-894X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10449
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China

Recommended Citation:
Xu, JJ; Ji, CJ; Zhang, YM; Su, J; Li, Y; Tan, NH.Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(4):1660-1663
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