Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
Wang, Li-Jun1,2; Geng, Chang-An1; Ma, Yun-Bao1; Huang, Xiao-Yan1; Luo, Jie1; Chen, Hao1,2; Zhang, Xue-Mei1; Chen, Ji-Jun1
2012-05-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号22期号:10页码:3473-3479
摘要Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC50 values of 5.71, 5.36, 8.90 and 9.08 mu M, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Glycyrrhetinic Acid Derivatives Anti-hbv Activity Structure-activity Relationships
资助信息National Natural Science Foundation of China for Distinguished Young Scholars[81025023]
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2012.03.081
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000303545900017
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10439
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Wang, Li-Jun,Geng, Chang-An,Ma, Yun-Bao,et al. Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(10):3473-3479.
APA Wang, Li-Jun.,Geng, Chang-An.,Ma, Yun-Bao.,Huang, Xiao-Yan.,Luo, Jie.,...&Chen, Ji-Jun.(2012).Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(10),3473-3479.
MLA Wang, Li-Jun,et al."Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.10(2012):3473-3479.
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