Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents

doi:10.1016/j.bmcl.2012.03.081

	Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
	Wang, Li-Jun 1,2; Geng, Chang-An 1; Ma, Yun-Bao 1; Huang, Xiao-Yan 1; Luo, Jie 1; Chen, Hao 1,2; Zhang, Xue-Mei 1; Chen, Ji-Jun1
	2012-05-15
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
卷号	22 期号:10 页码:3473-3479
摘要	Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC50 values of 5.71, 5.36, 8.90 and 9.08 mu M, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents. (C) 2012 Elsevier Ltd. All rights reserved.
关键词	Glycyrrhetinic Acid Derivatives Anti-hbv Activity Structure-activity Relationships
资助信息	National Natural Science Foundation of China for Distinguished Young Scholars[81025023]
学科领域	Chemistry, Medicinal ; Chemistry, Organic
DOI	10.1016/j.bmcl.2012.03.081
收录类别	SCI
语种	英语
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
WOS类目	Chemistry, Medicinal ; Chemistry, Organic
WOS记录号	WOS:000303545900017
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/10439
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Li-Jun,Geng, Chang-An,Ma, Yun-Bao,et al. Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(10):3473-3479.
APA	Wang, Li-Jun.,Geng, Chang-An.,Ma, Yun-Bao.,Huang, Xiao-Yan.,Luo, Jie.,...&Chen, Ji-Jun.(2012).Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(10),3473-3479.
MLA	Wang, Li-Jun,et al."Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.10(2012):3473-3479.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Wang-2012-Synthesis,（5043KB）			开放获取	--	请求全文