| Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents | |
Wang, Li-Jun1,2; Geng, Chang-An1 ; Ma, Yun-Bao1; Huang, Xiao-Yan1; Luo, Jie1; Chen, Hao1,2; Zhang, Xue-Mei1; Chen, Ji-Jun1
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| Corresponding Author | Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China, chenjj@mail.kib.ac.cn |
| 2012-05-15 | |
| Source Publication | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| Volume | 22Issue:10Pages:3473-3479 |
| Abstract | Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC50 values of 5.71, 5.36, 8.90 and 9.08 mu M, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents. (C) 2012 Elsevier Ltd. All rights reserved. |
| Keyword | Glycyrrhetinic Acid Derivatives Anti-hbv Activity Structure-activity Relationships |
| Subject Area | Chemistry, Medicinal ; Chemistry, Organic |
| DOI | 10.1016/j.bmcl.2012.03.081 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Pharmacology & Pharmacy ; Chemistry |
| WOS Subject | Chemistry, Medicinal ; Chemistry, Organic |
| WOS ID | WOS:000303545900017 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/10439 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Li-Jun,Geng, Chang-An,Ma, Yun-Bao,et al. Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(10):3473-3479. |
| APA | Wang, Li-Jun.,Geng, Chang-An.,Ma, Yun-Bao.,Huang, Xiao-Yan.,Luo, Jie.,...&Chen, Ji-Jun.(2012).Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(10),3473-3479. |
| MLA | Wang, Li-Jun,et al."Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.10(2012):3473-3479. |
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