Experimental and computational insights into the conformations of tunicyclin E, a new cycloheptapeptide from Psammosilene tunicoides
Tian, Jun-Mian1; Ou-Yang, Si-Sheng2; Zhang, Xu3; Di, Ying-Tong4; Jiang, Hua-Liang2,5; Li, Hong-Lin5; Dai, Wei-Xing1; Chen, Ke-Yu1; Liu, Mai-Li3; Hao, Xiao-Jiang4; Shen, Yun-Heng1; Luo, Cheng2; Zhang, Wei-Dong1
2012
发表期刊RSC ADVANCES
ISSN2046-2069
卷号2期号:3页码:1126-1135
摘要Tunicyclin E (1), a new cyclic heptapeptide, cyclo(Pro(1)-Ser(2)-Trp(3)-Leu(4)-Val(5)-Gly(6)-Ser(7)), was isolated from the root of Psammosilene tunicoides. The presence of two sets of resonance signals in its NMR spectra (1a:1b, similar to 3 : 1 abundance) indicated that it has two conformations in solution, while only one conformation was found in its crystal state by X-ray diffraction. To explore the molecular basis of the two conformations of 1 in solution and their interconversion mechanism, X-ray diffraction, NMR experiments, and theoretical calculations were performed. The results disclosed that two conformers of 1 in solution were derived from the cis/trans isomers of the Ser(7)-Pro(1) peptide bond (1a, trans; 1b, cis). The fast interconversion of the two conformations in solution is explained by an intramolecular catalysis mechanism and solvent effects. Furthermore, the existence of several unusual pseudo turns characterized for the first time plays a key role for dominant trans conformation in solution.
关键词Human-induced Erosion Land Degradation Logistic Regression Natural Erosion Soil Conservation Policy Highlands Decision Ethiopia Behavior China Area Risk
资助信息NCET Foundation; National Natural Science Foundation of China[30725045, 20972174, 91029704]; Ministry of Science and Technology, China[2009ZX09308-005, 2009ZX09311-001, 2008ZX09308-005]; Shanghai Leading Academic Discipline Project[B906]; Scientific Foundation of Shanghai, China[09DZ1975700, 09DZ1971500]; State Key Program of Basic Research of China[2009CB918502]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10429
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Wuhan Inst Phys & Math, Sate Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
5.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
推荐引用方式
GB/T 7714
Tian, Jun-Mian,Ou-Yang, Si-Sheng,Zhang, Xu,et al. Experimental and computational insights into the conformations of tunicyclin E, a new cycloheptapeptide from Psammosilene tunicoides[J]. RSC ADVANCES,2012,2(3):1126-1135.
APA Tian, Jun-Mian.,Ou-Yang, Si-Sheng.,Zhang, Xu.,Di, Ying-Tong.,Jiang, Hua-Liang.,...&Zhang, Wei-Dong.(2012).Experimental and computational insights into the conformations of tunicyclin E, a new cycloheptapeptide from Psammosilene tunicoides.RSC ADVANCES,2(3),1126-1135.
MLA Tian, Jun-Mian,et al."Experimental and computational insights into the conformations of tunicyclin E, a new cycloheptapeptide from Psammosilene tunicoides".RSC ADVANCES 2.3(2012):1126-1135.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Tian-2012-Experiment(820KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tian, Jun-Mian]的文章
[Ou-Yang, Si-Sheng]的文章
[Zhang, Xu]的文章
百度学术
百度学术中相似的文章
[Tian, Jun-Mian]的文章
[Ou-Yang, Si-Sheng]的文章
[Zhang, Xu]的文章
必应学术
必应学术中相似的文章
[Tian, Jun-Mian]的文章
[Ou-Yang, Si-Sheng]的文章
[Zhang, Xu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。