中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L
作者: Nian, Yin1, 2; Wang, Hai-Yan1, 2; Su, Jia1, 2; Zhou, Lin1; null(邱明华)1
刊名: FITOTERAPIA
关键词: Cimicifuga foetida ; 4 alpha-methyl steroid ; Cytotoxicity ; Cimisterol A
英文摘要: A new 4 alpha-methyl sterol, cimisterol A (1), together with five known compounds (2-6), were isolated from the aerial parts of Cimicifuga foetida L The new compound's structure was determined with the help of extensive 1D and 2D NMR spectroscopy. Compound 1 exhibited broad-spectrum and potent cytotoxic activities against human HL-60, Jurkat, K562, U937, HepG-2, and SGC-7091 cell lines, with IC50 values of 7.23, 2.89, 6.88, 3.38, 4.21, and 4.89 mu M, respectively. Compound 3 showed moderate to weak activities to all cell lines, except for SGC-7091, having 1050 values ranging from 13.37 to 17.72 mu M. This is the first time a cytotoxic 4 alpha-methyl sterol constituent was discovered from Cimicifuga spp. (C) 2011 Elsevier B.V. All rights reserved,
出版日期: 2012-03-01
卷号: 83, 期号:2, 页码:293-297
DOI标识: 10.1016/j.fitote.2011.11.001
语种: 英语
ISSN号: 0367-326X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10415
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Nian-2012-A cytotoxic 4 alpha-.pdf(279KB)----开放获取--View Download

作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Nian, Y; Wang, HY; Su, J; Zhou, L; Qiu, MH.A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L,FITOTERAPIA,2012,83(2):293-297
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Nian, Yin]'s Articles
[Wang, Hai-Yan]'s Articles
[Su, Jia]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Nian, Yin]‘s Articles
[Wang, Hai-Yan]‘s Articles
[Su, Jia]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Nian-2012-A cytotoxic 4 alpha-.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace