A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L
Nian, Yin1,2; Wang, Hai-Yan1,2; Su, Jia1,2; Zhou, Lin1; Qiu, Ming-Hua1
2012-03-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号83期号:2页码:293-297
摘要A new 4 alpha-methyl sterol, cimisterol A (1), together with five known compounds (2-6), were isolated from the aerial parts of Cimicifuga foetida L The new compound's structure was determined with the help of extensive 1D and 2D NMR spectroscopy. Compound 1 exhibited broad-spectrum and potent cytotoxic activities against human HL-60, Jurkat, K562, U937, HepG-2, and SGC-7091 cell lines, with IC50 values of 7.23, 2.89, 6.88, 3.38, 4.21, and 4.89 mu M, respectively. Compound 3 showed moderate to weak activities to all cell lines, except for SGC-7091, having 1050 values ranging from 13.37 to 17.72 mu M. This is the first time a cytotoxic 4 alpha-methyl sterol constituent was discovered from Cimicifuga spp. (C) 2011 Elsevier B.V. All rights reserved,
关键词Cimicifuga Foetida 4 Alpha-methyl Steroid Cytotoxicity Cimisterol a
资助信息National Natural Science Foundation of China[30772636]; CAS[KSCX2-YW-G-038, KSCX2-YW-R-194, KSCX2-YW-R-29, KSCX2-EW-R-15, KZCX2-XB2-15-03]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2008-ZZ05, P2010-ZZ14]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2011.11.001
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000300817000006
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10415
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Nian, Yin,Wang, Hai-Yan,Su, Jia,et al. A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L[J]. FITOTERAPIA,2012,83(2):293-297.
APA Nian, Yin,Wang, Hai-Yan,Su, Jia,Zhou, Lin,&Qiu, Ming-Hua.(2012).A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L.FITOTERAPIA,83(2),293-297.
MLA Nian, Yin,et al."A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L".FITOTERAPIA 83.2(2012):293-297.
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