| A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L | |
Nian, Yin1,2 ; Wang, Hai-Yan1,2; Su, Jia1,2; Zhou, Lin1; Qiu, Ming-Hua1
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| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China, mhchiu@mail.kib.ac.cn |
| 2012-03-01 | |
| 发表期刊 | FITOTERAPIA
 |
| ISSN | 0367-326X |
| 卷号 | 83期号:2页码:293-297 |
| 摘要 | A new 4 alpha-methyl sterol, cimisterol A (1), together with five known compounds (2-6), were isolated from the aerial parts of Cimicifuga foetida L The new compound's structure was determined with the help of extensive 1D and 2D NMR spectroscopy. Compound 1 exhibited broad-spectrum and potent cytotoxic activities against human HL-60, Jurkat, K562, U937, HepG-2, and SGC-7091 cell lines, with IC50 values of 7.23, 2.89, 6.88, 3.38, 4.21, and 4.89 mu M, respectively. Compound 3 showed moderate to weak activities to all cell lines, except for SGC-7091, having 1050 values ranging from 13.37 to 17.72 mu M. This is the first time a cytotoxic 4 alpha-methyl sterol constituent was discovered from Cimicifuga spp. (C) 2011 Elsevier B.V. All rights reserved, |
| 关键词 | Cimicifuga Foetida 4 Alpha-methyl Steroid Cytotoxicity Cimisterol a |
| 学科领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1016/j.fitote.2011.11.001 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300817000006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/10415 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nian, Yin,Wang, Hai-Yan,Su, Jia,et al. A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L[J]. FITOTERAPIA,2012,83(2):293-297. |
| APA | Nian, Yin,Wang, Hai-Yan,Su, Jia,Zhou, Lin,&Qiu, Ming-Hua.(2012).A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L.FITOTERAPIA,83(2),293-297. |
| MLA | Nian, Yin,et al."A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L".FITOTERAPIA 83.2(2012):293-297. |
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