Three new diterpenes from Jatropha curcas

doi:10.1016/j.tet.2011.12.006

	Three new diterpenes from Jatropha curcas
	Jie-Qing Liu; Yuan-Feng Yang; Cui-Fang Wang; Yan Li; Ming-Hua Qiu
通讯作者	Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources W China, Lanhei Rd 132, Kunming 650204, Yunnan, Peoples R China, mhchiu@mail.kib.ac.cn
	2012-01-28
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	68 期号:4 页码:972-976
摘要	Jatrophalactone (1) and jatrophalone (2), together with jatrophadiketone (3), a 6/6/6 tricyclic diterpene transformed from rhamnofolane skeleton, have been isolated from the methanolic extract of Jatropha curcas. The structures were established on the basis of extensive spectroscopic methods and further confirmed by X-ray crystallographic analysis. The cytotoxicity against selected cell lines was evaluated. Among them, compound 1 displayed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines with IC50 values of 8.5, 20.6, 19.7, 20.1, and 19.2 mu M, respectively. The possible biosynthetic pathways for 1 and 3 are proposed. (C) 2011 Elsevier Ltd. All rights reserved.
关键词	Jatropha Curcas Euphorbiaceae Diterpenoids Cytotoxicity
学科领域	Chemistry, Organic
DOI	10.1016/j.tet.2011.12.006
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000300028800004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/10405
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Jie-Qing Liu,Yuan-Feng Yang,Cui-Fang Wang,et al. Three new diterpenes from Jatropha curcas[J]. TETRAHEDRON,2012,68(4):972-976.
APA	Jie-Qing Liu,Yuan-Feng Yang,Cui-Fang Wang,Yan Li,&Ming-Hua Qiu.(2012).Three new diterpenes from Jatropha curcas.TETRAHEDRON,68(4),972-976.
MLA	Jie-Qing Liu,et al."Three new diterpenes from Jatropha curcas".TETRAHEDRON 68.4(2012):972-976.

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