Three new diterpenes from Jatropha curcas
Jie-Qing Liu; Yuan-Feng Yang; Cui-Fang Wang; Yan Li; Ming-Hua Qiu
2012-01-28
发表期刊TETRAHEDRON
ISSN0040-4020
卷号68期号:4页码:972-976
摘要Jatrophalactone (1) and jatrophalone (2), together with jatrophadiketone (3), a 6/6/6 tricyclic diterpene transformed from rhamnofolane skeleton, have been isolated from the methanolic extract of Jatropha curcas. The structures were established on the basis of extensive spectroscopic methods and further confirmed by X-ray crystallographic analysis. The cytotoxicity against selected cell lines was evaluated. Among them, compound 1 displayed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines with IC50 values of 8.5, 20.6, 19.7, 20.1, and 19.2 mu M, respectively. The possible biosynthetic pathways for 1 and 3 are proposed. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Jatropha Curcas Euphorbiaceae Diterpenoids Cytotoxicity
资助信息National Science & Technology Underpin Program[2007BAD32B01-03]; National Special Program of Basic Research[SB2007FY400]; CAS[KSCX2-YW-G-038, 29KZCXZ-XB2-15-03]
学科领域Chemistry, Organic
DOI10.1016/j.tet.2011.12.006
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000300028800004
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10405
专题植物化学与西部植物资源持续利用国家重点实验室
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Jie-Qing Liu,Yuan-Feng Yang,Cui-Fang Wang,et al. Three new diterpenes from Jatropha curcas[J]. TETRAHEDRON,2012,68(4):972-976.
APA Jie-Qing Liu,Yuan-Feng Yang,Cui-Fang Wang,Yan Li,&Ming-Hua Qiu.(2012).Three new diterpenes from Jatropha curcas.TETRAHEDRON,68(4),972-976.
MLA Jie-Qing Liu,et al."Three new diterpenes from Jatropha curcas".TETRAHEDRON 68.4(2012):972-976.
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