Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata

doi:10.1016/j.tet.2011.11.001

	Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata
	Li, Jin 1; Zhu, Huajie 2; Ren, Jinwei 1; Deng, Zhiwei 3; de Voogd, Nicole J.4; Proksch, Peter 5; Lin, Wenhan 1
通讯作者	Lin, WH (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China, whlin@bjmu.edu.cn
	2012-01-14
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	68 期号:2 页码:559-565
摘要	Nine new isomalabaricane-type triterpenoids namely globostelletins J-R (1-9) were isolated from the marine sponge Rhabdastrella globostellata. Their structures were established on the basis of extensive spectroscopic data analysis including IR, MS, 1D and 2D NMR, and CD spectra. Globostelletins J-R are characterized by the presence of an unusual cyclopentane unit linked at different positions of sidechains. These unprecedented structures enriched a number of new skeletons in isomalabaricane family. The biogenetic relationship of the isolated compounds is postulated. All compounds were tested for the inhibitory activities against human tumor-related protein kinases. (C) 2011 Elsevier Ltd. All rights reserved.
关键词	Marine Sponge Rhabdastrella Globostellata Globostelletins J-r Structural Elucidation Protein Kinase Inhibition
学科领域	Chemistry ; Organic
DOI	10.1016/j.tet.2011.11.001
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000299443900018
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/10395
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 2.CAS, Kunming Inst Bot, Kunming 650204, Peoples R China 3.Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100075, Peoples R China 4.Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands 5.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
推荐引用方式 GB/T 7714	Li, Jin,Zhu, Huajie,Ren, Jinwei,et al. Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata[J]. TETRAHEDRON,2012,68(2):559-565.
APA	Li, Jin.,Zhu, Huajie.,Ren, Jinwei.,Deng, Zhiwei.,de Voogd, Nicole J..,...&Lin, Wenhan.(2012).Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata.TETRAHEDRON,68(2),559-565.
MLA	Li, Jin,et al."Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata".TETRAHEDRON 68.2(2012):559-565.

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