Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata
Li, Jin1; Zhu, Huajie2; Ren, Jinwei1; Deng, Zhiwei3; de Voogd, Nicole J.4; Proksch, Peter5; Lin, Wenhan1
Corresponding AuthorLin, WH (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China, whlin@bjmu.edu.cn
2012-01-14
Source PublicationTETRAHEDRON
ISSN0040-4020
Volume68Issue:2Pages:559-565
AbstractNine new isomalabaricane-type triterpenoids namely globostelletins J-R (1-9) were isolated from the marine sponge Rhabdastrella globostellata. Their structures were established on the basis of extensive spectroscopic data analysis including IR, MS, 1D and 2D NMR, and CD spectra. Globostelletins J-R are characterized by the presence of an unusual cyclopentane unit linked at different positions of sidechains. These unprecedented structures enriched a number of new skeletons in isomalabaricane family. The biogenetic relationship of the isolated compounds is postulated. All compounds were tested for the inhibitory activities against human tumor-related protein kinases. (C) 2011 Elsevier Ltd. All rights reserved.
KeywordMarine Sponge Rhabdastrella Globostellata Globostelletins J-r Structural Elucidation Protein Kinase Inhibition
Subject AreaChemistry ; Organic
DOI10.1016/j.tet.2011.11.001
Indexed BySCI ; IC
Language英语
WOS IDWOS:000299443900018
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/10395
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.CAS, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100075, Peoples R China
4.Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands
5.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
Recommended Citation
GB/T 7714
Li, Jin,Zhu, Huajie,Ren, Jinwei,et al. Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata[J]. TETRAHEDRON,2012,68(2):559-565.
APA Li, Jin.,Zhu, Huajie.,Ren, Jinwei.,Deng, Zhiwei.,de Voogd, Nicole J..,...&Lin, Wenhan.(2012).Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata.TETRAHEDRON,68(2),559-565.
MLA Li, Jin,et al."Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata".TETRAHEDRON 68.2(2012):559-565.
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