Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata
Li, Jin1; Zhu, Huajie2; Ren, Jinwei1; Deng, Zhiwei3; de Voogd, Nicole J.4; Proksch, Peter5; Lin, Wenhan1
2012-01-14
发表期刊TETRAHEDRON
ISSN0040-4020
卷号68期号:2页码:559-565
摘要Nine new isomalabaricane-type triterpenoids namely globostelletins J-R (1-9) were isolated from the marine sponge Rhabdastrella globostellata. Their structures were established on the basis of extensive spectroscopic data analysis including IR, MS, 1D and 2D NMR, and CD spectra. Globostelletins J-R are characterized by the presence of an unusual cyclopentane unit linked at different positions of sidechains. These unprecedented structures enriched a number of new skeletons in isomalabaricane family. The biogenetic relationship of the isolated compounds is postulated. All compounds were tested for the inhibitory activities against human tumor-related protein kinases. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Marine Sponge Rhabdastrella Globostellata Globostelletins J-r Structural Elucidation Protein Kinase Inhibition
资助信息NSFC[30672607]; National Hi-Tech 863-Projects[2010DFA31610]; BMBF/MOST
学科领域Chemistry ; Organic
DOI10.1016/j.tet.2011.11.001
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000299443900018
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10395
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.CAS, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100075, Peoples R China
4.Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands
5.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
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Li, Jin,Zhu, Huajie,Ren, Jinwei,et al. Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata[J]. TETRAHEDRON,2012,68(2):559-565.
APA Li, Jin.,Zhu, Huajie.,Ren, Jinwei.,Deng, Zhiwei.,de Voogd, Nicole J..,...&Lin, Wenhan.(2012).Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata.TETRAHEDRON,68(2),559-565.
MLA Li, Jin,et al."Globostelletins J-S, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata".TETRAHEDRON 68.2(2012):559-565.
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