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题名: Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.
作者: Huang, Sheng Zhuo1, 4; Zhang, Xing Jie3, 4; Li, Xing Yao3, 4; Kong, Ling Mei1, 4; Jiang, He Zhong1, 4; Ma, Qing Yun2; Liu, Yu Qing1; Hu, Jiang Miao1; Zheng, Yong Tang3; null(李艳)1; Zhou, Jun1; Zhao, You Xing1, 2
刊名: PHYTOCHEMISTRY
关键词: Daphne acutiloba ; Thymelaeaceae ; Daphnane ; Diterpene ester ; Cytotoxicity ; Anti-HIV-1
英文摘要: Seven previously unreported daphnane-type diterpene esters named acutilobins A-G, together with 12 known ones, were isolated from EtOAc extract of Daphne acutiloba Rehd. Their structures were elucidated based on the spectroscopic data. The cytotoxic and anti-HIV-1 activities of these daphnane-type diterpene esters were evaluated through bioassays. Fourteen of these isolates exhibited definite cytotoxic activities against the five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. Additionally, anti-HIV-1 activities were observed in.13 daphnane-type diterpene esters, among which acutilobins A-G exhibited significant anti-HIV-1 activities with EC50 below 1.5 nM and SI over 10,000. Particularly, genkwanineVIII showed the strongest activity with EC50 0.17 nM and SI 187,010. (C) 2011 Elsevier Ltd. All rights reserved.
出版日期: 2012-03-01
卷号: 75, 页码:99-107
DOI标识: 10.1016/j.phytochem.2011.11.013
语种: 英语
收录类别: SCI ; IC
学科分类: Biochemistry & Molecular Biology; Plant Sciences
ISSN号: 0031-9422
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10381
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650204, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Huang, SZ; Zhang, XJ; Li, XY; Kong, LM; Jiang, HZ; Ma, QY; Liu, YQ; Hu, JM; Zheng, YT; Li, Y; Zhou, J; Zhao, YX.Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.,PHYTOCHEMISTRY,2012,75():99-107
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