| Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd. | |
Huang, Sheng Zhuo1,4; Zhang, Xing Jie3,4; Li, Xing Yao3,4; Kong, Ling Mei1,4; Jiang, He Zhong1,4; Ma, Qing Yun2; Liu, Yu Qing1; Hu, Jiang Miao1; Zheng, Yong Tang3; Li, Yan1 ; Zhou, Jun1; Zhao, You Xing1,2
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| 通讯作者 | Zhou, J (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China, jzhou@mail.kib.ac.cn ; zhaoyx1011@163.com |
| 2012-03-01 | |
| 发表期刊 | PHYTOCHEMISTRY
 |
| ISSN | 0031-9422 |
| 卷号 | 75页码:99-107 |
| 摘要 | Seven previously unreported daphnane-type diterpene esters named acutilobins A-G, together with 12 known ones, were isolated from EtOAc extract of Daphne acutiloba Rehd. Their structures were elucidated based on the spectroscopic data. The cytotoxic and anti-HIV-1 activities of these daphnane-type diterpene esters were evaluated through bioassays. Fourteen of these isolates exhibited definite cytotoxic activities against the five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. Additionally, anti-HIV-1 activities were observed in.13 daphnane-type diterpene esters, among which acutilobins A-G exhibited significant anti-HIV-1 activities with EC50 below 1.5 nM and SI over 10,000. Particularly, genkwanineVIII showed the strongest activity with EC50 0.17 nM and SI 187,010. (C) 2011 Elsevier Ltd. All rights reserved. |
| 关键词 | Daphne Acutiloba Thymelaeaceae Daphnane Diterpene Ester Cytotoxicity Anti-hiv-1 |
| 学科领域 | Biochemistry & Molecular Biology ; Plant Sciences |
| DOI | 10.1016/j.phytochem.2011.11.013 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000300868600011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/10381 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650204, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Sheng Zhuo,Zhang, Xing Jie,Li, Xing Yao,et al. Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.[J]. PHYTOCHEMISTRY,2012,75:99-107. |
| APA | Huang, Sheng Zhuo.,Zhang, Xing Jie.,Li, Xing Yao.,Kong, Ling Mei.,Jiang, He Zhong.,...&Zhao, You Xing.(2012).Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd..PHYTOCHEMISTRY,75,99-107. |
| MLA | Huang, Sheng Zhuo,et al."Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.".PHYTOCHEMISTRY 75(2012):99-107. |
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