Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.
Huang, Sheng Zhuo1,4; Zhang, Xing Jie3,4; Li, Xing Yao3,4; Kong, Ling Mei1,4; Jiang, He Zhong1,4; Ma, Qing Yun2; Liu, Yu Qing1; Hu, Jiang Miao1; Zheng, Yong Tang3; Li, Yan1; Zhou, Jun1; Zhao, You Xing1,2
2012-03-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号75页码:99-107
摘要Seven previously unreported daphnane-type diterpene esters named acutilobins A-G, together with 12 known ones, were isolated from EtOAc extract of Daphne acutiloba Rehd. Their structures were elucidated based on the spectroscopic data. The cytotoxic and anti-HIV-1 activities of these daphnane-type diterpene esters were evaluated through bioassays. Fourteen of these isolates exhibited definite cytotoxic activities against the five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. Additionally, anti-HIV-1 activities were observed in.13 daphnane-type diterpene esters, among which acutilobins A-G exhibited significant anti-HIV-1 activities with EC50 below 1.5 nM and SI over 10,000. Particularly, genkwanineVIII showed the strongest activity with EC50 0.17 nM and SI 187,010. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Daphne Acutiloba Thymelaeaceae Daphnane Diterpene Ester Cytotoxicity Anti-hiv-1
资助信息CATAS-ITBB[110301]; Natural Science Foundation of Yunnan[2008CD159]
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2011.11.013
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000300868600011
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10381
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650204, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Huang, Sheng Zhuo,Zhang, Xing Jie,Li, Xing Yao,et al. Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.[J]. PHYTOCHEMISTRY,2012,75:99-107.
APA Huang, Sheng Zhuo.,Zhang, Xing Jie.,Li, Xing Yao.,Kong, Ling Mei.,Jiang, He Zhong.,...&Zhao, You Xing.(2012).Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd..PHYTOCHEMISTRY,75,99-107.
MLA Huang, Sheng Zhuo,et al."Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.".PHYTOCHEMISTRY 75(2012):99-107.
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