Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.
Huang, Sheng Zhuo1,4; Zhang, Xing Jie3,4; Li, Xing Yao3,4; Kong, Ling Mei1,4; Jiang, He Zhong1,4; Ma, Qing Yun2; Liu, Yu Qing1; Hu, Jiang Miao1; Zheng, Yong Tang3; Li, Yan1; Zhou, Jun1; Zhao, You Xing1,2
Corresponding AuthorZhou, J (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China, jzhou@mail.kib.ac.cn ; zhaoyx1011@163.com
2012-03-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume75Pages:99-107
AbstractSeven previously unreported daphnane-type diterpene esters named acutilobins A-G, together with 12 known ones, were isolated from EtOAc extract of Daphne acutiloba Rehd. Their structures were elucidated based on the spectroscopic data. The cytotoxic and anti-HIV-1 activities of these daphnane-type diterpene esters were evaluated through bioassays. Fourteen of these isolates exhibited definite cytotoxic activities against the five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. Additionally, anti-HIV-1 activities were observed in.13 daphnane-type diterpene esters, among which acutilobins A-G exhibited significant anti-HIV-1 activities with EC50 below 1.5 nM and SI over 10,000. Particularly, genkwanineVIII showed the strongest activity with EC50 0.17 nM and SI 187,010. (C) 2011 Elsevier Ltd. All rights reserved.
KeywordDaphne Acutiloba Thymelaeaceae Daphnane Diterpene Ester Cytotoxicity Anti-hiv-1
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2011.11.013
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000300868600011
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/10381
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650204, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Huang, Sheng Zhuo,Zhang, Xing Jie,Li, Xing Yao,et al. Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.[J]. PHYTOCHEMISTRY,2012,75:99-107.
APA Huang, Sheng Zhuo.,Zhang, Xing Jie.,Li, Xing Yao.,Kong, Ling Mei.,Jiang, He Zhong.,...&Zhao, You Xing.(2012).Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd..PHYTOCHEMISTRY,75,99-107.
MLA Huang, Sheng Zhuo,et al."Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.".PHYTOCHEMISTRY 75(2012):99-107.
Files in This Item: Download All
File Name/Size DocType Version Access License
Huang-2012-Daphnane-(516KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Huang, Sheng Zhuo]'s Articles
[Zhang, Xing Jie]'s Articles
[Li, Xing Yao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Huang, Sheng Zhuo]'s Articles
[Zhang, Xing Jie]'s Articles
[Li, Xing Yao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Huang, Sheng Zhuo]'s Articles
[Zhang, Xing Jie]'s Articles
[Li, Xing Yao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Huang-2012-Daphnane-type diterp.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.