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题名: Two new phenolic constituents from Clematis connata DC.
作者: Yuan, Lin1; Huang, Wenzhong1; Ma, Yinhai; null(杜芝芝)2
刊名: AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
关键词: Clematis connata DC. ; phenolic constituents ; cytotoxicities ; antibacterial activities
英文摘要: Two new phenolic compounds, 3,4-dihydroxyphenethyl 5-hydroxy-4-oxopentanoate (1) and 3-(4-hydroxy-2,5-dimethoxyphenyl)-3-oxopropyl acetate (2), together with fifteen known compounds, 3 to 17, were isolated from the dried whole plants of Clematis connata DC. Their structures were elucidated by extensive spectral analysis, especially 2D NMR techniques. Compounds 1 to 5 were evaluated for their in vitro cytotoxicities against acute promyelocytic leukemia HL-60, hepatocellular carcinoma Hep-G2, oropharyngeal epidermoid carcinoma KB and breast cancer cells MDA-MB-231. Compounds 1 and 3 exhibited the most potential with IC50 values of 0.63 and 1.27 mu M against MDA-MB-231 and HepG2, respectively. The antibacterial activities experiment of all the isolated compounds showed that only Compounds 3 to 5 exhibited weak activities against Staphylococcus aureus, methcillin-resistant S. aureus and beta-lactamase positive S. aureus, and Compound 9 and 17 showed weak activities against S. aureus.
出版日期: 2012-04-01
卷号: 6, 期号:14, 页码:1050-1055
DOI标识: 10.5897/AJPP12.159
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy
ISSN号: 1996-0816
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10353
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Kunming Univ, Chem Sci & Technol Dept, Kunming 650214, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

Recommended Citation:
Yuan, L; Huang, WZ; Ma, YH; Du, ZZ.Two new phenolic constituents from Clematis connata DC.,AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY,2012,6(14):1050-1055
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