| Two new phenolic constituents from Clematis connata DC. | |
Yuan, Lin1; Huang, Wenzhong1; Ma, Yinhai; Du, Zhizhi2
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| 通讯作者 | , myh5929251@hotmail.com |
| 2012-04-01 | |
| 发表期刊 | AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
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| ISSN | 1996-0816 |
| 卷号 | 6期号:14页码:1050-1055 |
| 摘要 | Two new phenolic compounds, 3,4-dihydroxyphenethyl 5-hydroxy-4-oxopentanoate (1) and 3-(4-hydroxy-2,5-dimethoxyphenyl)-3-oxopropyl acetate (2), together with fifteen known compounds, 3 to 17, were isolated from the dried whole plants of Clematis connata DC. Their structures were elucidated by extensive spectral analysis, especially 2D NMR techniques. Compounds 1 to 5 were evaluated for their in vitro cytotoxicities against acute promyelocytic leukemia HL-60, hepatocellular carcinoma Hep-G2, oropharyngeal epidermoid carcinoma KB and breast cancer cells MDA-MB-231. Compounds 1 and 3 exhibited the most potential with IC50 values of 0.63 and 1.27 mu M against MDA-MB-231 and HepG2, respectively. The antibacterial activities experiment of all the isolated compounds showed that only Compounds 3 to 5 exhibited weak activities against Staphylococcus aureus, methcillin-resistant S. aureus and beta-lactamase positive S. aureus, and Compound 9 and 17 showed weak activities against S. aureus. |
| 关键词 | Clematis Connata Dc. Phenolic Constituents Cytotoxicities Antibacterial Activities |
| 学科领域 | Pharmacology & Pharmacy |
| DOI | 10.5897/AJPP12.159 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000303768800006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/10353 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Univ, Chem Sci & Technol Dept, Kunming 650214, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Lin,Huang, Wenzhong,Ma, Yinhai,et al. Two new phenolic constituents from Clematis connata DC.[J]. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY,2012,6(14):1050-1055. |
| APA | Yuan, Lin,Huang, Wenzhong,Ma, Yinhai,&Du, Zhizhi.(2012).Two new phenolic constituents from Clematis connata DC..AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY,6(14),1050-1055. |
| MLA | Yuan, Lin,et al."Two new phenolic constituents from Clematis connata DC.".AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 6.14(2012):1050-1055. |
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