Two new phenolic constituents from Clematis connata DC.
Yuan, Lin1; Huang, Wenzhong1; Ma, Yinhai; Du, Zhizhi2
2012-04-01
发表期刊AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
ISSN1996-0816
卷号6期号:14页码:1050-1055
摘要Two new phenolic compounds, 3,4-dihydroxyphenethyl 5-hydroxy-4-oxopentanoate (1) and 3-(4-hydroxy-2,5-dimethoxyphenyl)-3-oxopropyl acetate (2), together with fifteen known compounds, 3 to 17, were isolated from the dried whole plants of Clematis connata DC. Their structures were elucidated by extensive spectral analysis, especially 2D NMR techniques. Compounds 1 to 5 were evaluated for their in vitro cytotoxicities against acute promyelocytic leukemia HL-60, hepatocellular carcinoma Hep-G2, oropharyngeal epidermoid carcinoma KB and breast cancer cells MDA-MB-231. Compounds 1 and 3 exhibited the most potential with IC50 values of 0.63 and 1.27 mu M against MDA-MB-231 and HepG2, respectively. The antibacterial activities experiment of all the isolated compounds showed that only Compounds 3 to 5 exhibited weak activities against Staphylococcus aureus, methcillin-resistant S. aureus and beta-lactamase positive S. aureus, and Compound 9 and 17 showed weak activities against S. aureus.
关键词Clematis Connata Dc. Phenolic Constituents Cytotoxicities Antibacterial Activities
资助信息Yunnan Education Department of China[09Z0075]; Science and Technology Commission Foundation of Yunnan Province[2009ZC139M]; Science Foundation of Education Ministry of China[210203]
学科领域Pharmacology & Pharmacy
DOI10.5897/AJPP12.159
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000303768800006
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10353
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Kunming Univ, Chem Sci & Technol Dept, Kunming 650214, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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Yuan, Lin,Huang, Wenzhong,Ma, Yinhai,et al. Two new phenolic constituents from Clematis connata DC.[J]. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY,2012,6(14):1050-1055.
APA Yuan, Lin,Huang, Wenzhong,Ma, Yinhai,&Du, Zhizhi.(2012).Two new phenolic constituents from Clematis connata DC..AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY,6(14),1050-1055.
MLA Yuan, Lin,et al."Two new phenolic constituents from Clematis connata DC.".AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 6.14(2012):1050-1055.
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