Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities

	Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities
	Lu, Lu 1,2; Chen, Jian-Chao 1; Li, Yan1 ; Qing, Chen 3; Wang, Yuan-Yuan 1; Nian, Yin1,2 ; Qiu, Ming-Hua1
通讯作者	Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China, mhchiu@mail.kib.ac.cn
	2012-05-01
发表期刊	CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN	0009-2363
卷号	60 期号:5 页码:571-577
摘要	Two new triterpenoids and a chromone glycoside, namely, 24-epi-cimigenol-3-one (1), foetinoside (2), cimifugin-4'-O-[6 ''-feruloyl]-beta-D-glucopyranoside (3), together with 18 known compounds, were isolated from the rhizomes of Cimicifuga foetida L. collected in Guizhou Province, China. All of the compounds were identified by spectroscopic methods, as well as chemical methods. In the in vitro cytotoxicity evaluation of these compounds against 5 human cancer cell lines, cimigenol (8) exerted the most potent cytotoxic activity against SMMC-7721 (7.87 mu M) and A-549 (12.16 mu M), while cimiacerin B (9) also showed obvious cytotoxicity against the A-549 cell line, with an IC50 value of 16.77 mu M.
关键词	Cimicifuga Foetida Cycloartane Cytotoxicity Ranunculaceae
学科领域	Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000303293000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/10351
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Kunming Med Coll, Kunming 650031, Peoples R China
推荐引用方式 GB/T 7714	Lu, Lu,Chen, Jian-Chao,Li, Yan,et al. Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2012,60(5):571-577.
APA	Lu, Lu.,Chen, Jian-Chao.,Li, Yan.,Qing, Chen.,Wang, Yuan-Yuan.,...&Qiu, Ming-Hua.(2012).Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities.CHEMICAL & PHARMACEUTICAL BULLETIN,60(5),571-577.
MLA	Lu, Lu,et al."Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities".CHEMICAL & PHARMACEUTICAL BULLETIN 60.5(2012):571-577.

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