Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities
Lu, Lu1,2; Chen, Jian-Chao1; Li, Yan1; Qing, Chen3; Wang, Yuan-Yuan1; Nian, Yin1,2; Qiu, Ming-Hua1
2012-05-01
发表期刊CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN0009-2363
卷号60期号:5页码:571-577
摘要Two new triterpenoids and a chromone glycoside, namely, 24-epi-cimigenol-3-one (1), foetinoside (2), cimifugin-4'-O-[6 ''-feruloyl]-beta-D-glucopyranoside (3), together with 18 known compounds, were isolated from the rhizomes of Cimicifuga foetida L. collected in Guizhou Province, China. All of the compounds were identified by spectroscopic methods, as well as chemical methods. In the in vitro cytotoxicity evaluation of these compounds against 5 human cancer cell lines, cimigenol (8) exerted the most potent cytotoxic activity against SMMC-7721 (7.87 mu M) and A-549 (12.16 mu M), while cimiacerin B (9) also showed obvious cytotoxicity against the A-549 cell line, with an IC50 value of 16.77 mu M.
关键词Cimicifuga Foetida Cycloartane Cytotoxicity Ranunculaceae
资助信息Foundation of Key State Lab. of Phytochemistry and Plant Resources in West China[P2008ZZ05]; Cooperative Project of Guangdong Province; CAS[2009B09 1300135, KSCX2-YW-G-038, KSCX2-YW-R-194, 29KZCX2-XB2-15-03]; National Natural Science Foundation of China[30772636]
学科领域Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS记录号WOS:000303293000001
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10351
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Kunming Med Coll, Kunming 650031, Peoples R China
推荐引用方式
GB/T 7714
Lu, Lu,Chen, Jian-Chao,Li, Yan,et al. Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2012,60(5):571-577.
APA Lu, Lu.,Chen, Jian-Chao.,Li, Yan.,Qing, Chen.,Wang, Yuan-Yuan.,...&Qiu, Ming-Hua.(2012).Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities.CHEMICAL & PHARMACEUTICAL BULLETIN,60(5),571-577.
MLA Lu, Lu,et al."Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities".CHEMICAL & PHARMACEUTICAL BULLETIN 60.5(2012):571-577.
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