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题名: Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities
作者: Lu, Lu1, 2; Chen, Jian-Chao1; null(李艳)1; Qing, Chen3; Wang, Yuan-Yuan1; Nian, Yin1, 2; null(邱明华)1
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
关键词: Cimicifuga foetida ; cycloartane ; cytotoxicity ; Ranunculaceae
英文摘要: Two new triterpenoids and a chromone glycoside, namely, 24-epi-cimigenol-3-one (1), foetinoside (2), cimifugin-4'-O-[6 ''-feruloyl]-beta-D-glucopyranoside (3), together with 18 known compounds, were isolated from the rhizomes of Cimicifuga foetida L. collected in Guizhou Province, China. All of the compounds were identified by spectroscopic methods, as well as chemical methods. In the in vitro cytotoxicity evaluation of these compounds against 5 human cancer cell lines, cimigenol (8) exerted the most potent cytotoxic activity against SMMC-7721 (7.87 mu M) and A-549 (12.16 mu M), while cimiacerin B (9) also showed obvious cytotoxicity against the A-549 cell line, with an IC50 value of 16.77 mu M.
出版日期: 2012-05-01
卷号: 60, 期号:5, 页码:571-577
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy
ISSN号: 0009-2363
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10351
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Kunming Med Coll, Kunming 650031, Peoples R China

Recommended Citation:
Lu, L; Chen, JC; Li, Y; Qing, C; Wang, YY; Nian, Y; Qiu, MH.Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities,CHEMICAL & PHARMACEUTICAL BULLETIN,2012,60(5):571-577
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