Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex

doi:10.1016/j.biopha.2024.116784

KIB OpenIR

	Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex
	Tan, Xin; Xu, Rui; Li, Ai -Pei; Li, Dan; Wang, Yun; Zhao, Qian; Long, Li-Ping; Fan, Yu-Zhou; Zhao, Chen-Xiao; Liu, Yan; Li, Sheng-Hong
	2024
发表期刊	BIOMEDICINE & PHARMACOTHERAPY
ISSN	0753-3322
卷号	175 页码:116784
摘要	1,8-Cineole is a bicyclic monoterpene widely distributed in the essential oils of various medicinal plants, and it exhibits significant anti-inflammatory and antioxidant activities. We aimed to investigate the therapeutic effect of 1,8-cineole on anti-Alzheimer's disease by using transgenic Caenorhabditis elegans models. Our studies demonstrated that 1,8-cineole significantly relieved Afl1-42-induced paralysis and exhibited remarkable antioxidant and anti-Afl1-42 aggregation activities in transgenic nematodes CL4176, CL2006 and CL2355. We developed a 1,8-cineole/cyclodextrin inclusion complex, displaying enhanced anti-paralysis, anti-Afl aggregation and antioxidant activities compared to 1,8-cineole. In addition, we found 1,8-cineole treatment activated the SKN-1/ Nrf-2 pathway and induced autophagy in nematodes. Our results demonstrated the antioxidant and anti-Alzheimer's disease activities of 1,8-cineole, which provide a potential therapeutic approach for Alzheimer's disease.
DOI	10.1016/j.biopha.2024.116784
WOS记录号	WOS:001264214300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76332
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Tan, Xin,Xu, Rui,Li, Ai -Pei,et al. Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex[J]. BIOMEDICINE & PHARMACOTHERAPY,2024,175:116784.
APA	Tan, Xin.,Xu, Rui.,Li, Ai -Pei.,Li, Dan.,Wang, Yun.,...&Li, Sheng-Hong.(2024).Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex.BIOMEDICINE & PHARMACOTHERAPY,175,116784.
MLA	Tan, Xin,et al."Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex".BIOMEDICINE & PHARMACOTHERAPY 175(2024):116784.

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