In vitro and vivo anti-tumor activity and mechanisms of the new cryptotanshinone derivative 11 against hepatocellular carcinoma

doi:10.1016/j.ejphar.2024.176522

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	In vitro and vivo anti-tumor activity and mechanisms of the new cryptotanshinone derivative 11 against hepatocellular carcinoma
	Yang, Xinni; She, Xianlan; Zhao, Zhishuang; Ren, Jian; Wang, Peiying; Dong, Haoqi; Zhao, Qin-shi; Liu, Jiangxin
	2024
发表期刊	EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN	0014-2999
卷号	971 页码:176522
摘要	Global burden of hepatocellular carcinoma (HCC) is increasing. Chemotherapy and immunotherapy are the prevailing options for therapy. Developing new therapeutic strategies for HCC patients is still highly desirable. Recent studies demonstrate that cryptotanshinone is capable of inhibiting tumor growth in HCC and induces antitumor immunity in vitro . In our previous research, we discovered a new cryptotanshinone derivative 11 as an effective immunoregulatory enzyme indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor. This study aims to evaluate its in vitro and in vivo antitumor activity against hepatocellular carcinoma. 11 displayed robust antiproliferative activity against HCC cell lines and promoted apoptosis of HCC cell line through the mitochondrial-mediated apoptotic pathway. In H22 tumor-bearing mice models, 11 exhibited significant in vivo anti -tumor activity with different administration routes. And no obvious toxicity was observed. RNA-seq analysis demonstrated the differential expressed genes and alteration of key pathways associated with immune responses after administration of 11 . Up-regulation of anti -tumor cytokines and down-regulation of cytokines that promote tumor growth were indicated and further validated. Our study demonstrates that 11 exhibits promising antitumor activity both in vitro and in vivo against hepatocellular carcinoma cancer. It is a lead compound for HCC immunotherapy and is worthy for further development.
DOI	10.1016/j.ejphar.2024.176522
WOS记录号	WOS:001215239800001
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76298
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yang, Xinni,She, Xianlan,Zhao, Zhishuang,et al. In vitro and vivo anti-tumor activity and mechanisms of the new cryptotanshinone derivative 11 against hepatocellular carcinoma[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2024,971:176522.
APA	Yang, Xinni.,She, Xianlan.,Zhao, Zhishuang.,Ren, Jian.,Wang, Peiying.,...&Liu, Jiangxin.(2024).In vitro and vivo anti-tumor activity and mechanisms of the new cryptotanshinone derivative 11 against hepatocellular carcinoma.EUROPEAN JOURNAL OF PHARMACOLOGY,971,176522.
MLA	Yang, Xinni,et al."In vitro and vivo anti-tumor activity and mechanisms of the new cryptotanshinone derivative 11 against hepatocellular carcinoma".EUROPEAN JOURNAL OF PHARMACOLOGY 971(2024):176522.

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