Cytotoxicities of cucurbitacins from the stem bark of Aquilaria sinensis

doi:10.1016/j.phytol.2024.02.011

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	Cytotoxicities of cucurbitacins from the stem bark of Aquilaria sinensis
	Chen, Xiao-Yu; Yang, Jun; Yang, Xing-Zhi; Luo, Ji-Feng; Duan, Xiao-Yan; Hu, Dong-Bao; Wang, Yue-Hu
	2024
发表期刊	PHYTOCHEMISTRY LETTERS
ISSN	1874-3900
卷号	60 页码:190-193
摘要	One previously undescribed cucurbitacin, 11-hydrocucurbitacin B (1), and five known analogs, 3-epicucurbitacin Q1 (2), cucurbitacin Q1 (3), cucurbitacin D (4), isocucurbitacin D (5), and hemslecin A (6), were isolated from the stem bark of Aquilaria sinensis (Thymelaeaceae). The chemical structure of 11-hydrocucurbitacin B was elucidated by MS and NMR analysis and ECD calculations. All the isolates were evaluated for their cytotoxicity against seven human cancer cell lines, namely, gastric cancer HGC-27 and AGS cells, leukemia HL-60 cells, breast cancer MDA-MB-231 cells, colon cancer SW480 cells, lung adenocarcinoma A549 cells, and paclitaxel-resistant A549 (A549/Taxol) cells, in addition to the normal human bronchial epithelial cell line BEAS-2B. Cucurbitacin Q1 exhibited the most potent inhibitory activity against these seven cancer cell lines, with IC50 values ranging from 0.017 mu M to 7.68 mu M. The previously undescribed compound, 11-hydrocucurbitacin B exhibited moderate inhibitory effects on AGS (IC50 = 2.66 mu M), HGC-27 (IC50 = 0.54 mu M), SW480 (IC50 = 3.94 mu M), A549 (IC50 = 0.51 mu M), and A549/Taxol (IC50 = 2.39 mu M) cell lines, with low toxicity toward normal BEAS-2B cells (IC50 > 40 mu M).
DOI	10.1016/j.phytol.2024.02.011
WOS记录号	WOS:001204395200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76283
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Chen, Xiao-Yu,Yang, Jun,Yang, Xing-Zhi,et al. Cytotoxicities of cucurbitacins from the stem bark of Aquilaria sinensis[J]. PHYTOCHEMISTRY LETTERS,2024,60:190-193.
APA	Chen, Xiao-Yu.,Yang, Jun.,Yang, Xing-Zhi.,Luo, Ji-Feng.,Duan, Xiao-Yan.,...&Wang, Yue-Hu.(2024).Cytotoxicities of cucurbitacins from the stem bark of Aquilaria sinensis.PHYTOCHEMISTRY LETTERS,60,190-193.
MLA	Chen, Xiao-Yu,et al."Cytotoxicities of cucurbitacins from the stem bark of Aquilaria sinensis".PHYTOCHEMISTRY LETTERS 60(2024):190-193.

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