Evaluation of the sedative-hypnotic effects of Menyanthes trifoliata L. extract in mice

doi:10.1016/j.jep.2024.119227

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	Evaluation of the sedative-hypnotic effects of Menyanthes trifoliata L. extract in mice
	Gong, Ranran; Jiang, Haizhou; Hu, Jin; Liu, Guohua; Gao, Lingxiao; Zhang, Qingwen; Wei, Yutong; Geng, Changan; Wei, Shanshan
	2025
发表期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
卷号	340 页码:119227
摘要	Ethnopharmacological relevance: Insomnia is a pervasive and prominent problem worldwide, afflicting approximately one-third of the population and profoundly affecting patients' quality of life. Efficient and safe sedativehypnotic medications are required. Menyanthes trifoliata L. (Mt), a sleeping herb in China, is used as a hypnotic remedy in ethnomedicines; however, there are few studies on this herb. Aim of the study: We systematically evaluated the potential of Mt as a sedative-hypnotic candidate. Materials and methods: The chemical constituents of the Mt extract were analyzed by lLiquid chromatography with photodiode array detection and mass spectrometry (LC-PDA-MS). The sedative-hypnotic effects of Mt extract (0.5, 2, and 4 g/kg) were investigated using the pentobarbital-induced sleep test (PIST), the caffeineinduced insomnia model (CIIM), and the open field test (OFT). Furthermore, the effect of Mt on sleep architecture was investigated using electroencephalography/electromyography (EEG/EMG). The safety of the Mt extract was evaluated using the maximum tolerated dose method. Results: Fifteen phenolic compounds were identified based on their UV absorption and MS fragmentation using LC-PDA-MS analysis. In the CIIM, PIST, and OFT, Mt extract exhibited a dose-dependent reduction in sleep latency, an extension of total sleep duration, and a decrease in locomotor activity. Moreover, it increased the duration of non-rapid eye movement (NREM) sleep and reduced wakefulness after one day's administration, according to EEG/EMG. Additionally, no signs of toxicity were observed at a dose of 30 g/kg (equivalent to 316.46 g/kg of crude drugs). Conclusion: This study supports the potential medicinal use of Mt extract for sleep promotion.
DOI	10.1016/j.jep.2024.119227
WOS记录号	WOS:001389444400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76210
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Gong, Ranran,Jiang, Haizhou,Hu, Jin,et al. Evaluation of the sedative-hypnotic effects of Menyanthes trifoliata L. extract in mice[J]. JOURNAL OF ETHNOPHARMACOLOGY,2025,340:119227.
APA	Gong, Ranran.,Jiang, Haizhou.,Hu, Jin.,Liu, Guohua.,Gao, Lingxiao.,...&Wei, Shanshan.(2025).Evaluation of the sedative-hypnotic effects of Menyanthes trifoliata L. extract in mice.JOURNAL OF ETHNOPHARMACOLOGY,340,119227.
MLA	Gong, Ranran,et al."Evaluation of the sedative-hypnotic effects of Menyanthes trifoliata L. extract in mice".JOURNAL OF ETHNOPHARMACOLOGY 340(2025):119227.

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