Siegesoxylipin A-J, previously undescribed phyto-oxylipins inhibition of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci from Sigesbeckia orientalis

doi:10.1016/j.phytochem.2024.114355

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	Siegesoxylipin A-J, previously undescribed phyto-oxylipins inhibition of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci from Sigesbeckia orientalis
	Zhou, Zhong-Shun; Zu, Wen-Biao; Zhu, Yan-Yan; Wei, Mei-Zhen; Jiang, Yue-Ming; Wang, Zhao-Jie; Zhao, Yun-Li; Luo, Xiao-Dong
	2025
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	231 页码:114355
摘要	Ten previously undescribed phyto-oxylipins siegesoxylipin A-J (1-10), along with four known analogs (11-14), were isolated from the aerial parts of Sigesbeckia orientalis. The elucidation of their structures was accomplished through spectroscopic analyses, base-catalyzed hydrolysis and X-ray diffraction. Moreover, unmethylesterified 4methylpentanoic acid siegesoxylipins 1, 2, and 4-7 exhibited potent inhibitory bioactivity against methicillinresistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) strains with MIC values of 8 mu g/mL, in which siegesoxylipin A (1) inhibited bacteria by inducing membrane damage. Siegesoxylipins represent an original class of anti-MRSA and anti-VRE agents with 4-methylpentanoates incorporating fatty acid moieties. This discovery holds promise for the development of new therapeutic strategies to combat antibioticresistant infections.
DOI	10.1016/j.phytochem.2024.114355
WOS记录号	WOS:001388059600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76208
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhou, Zhong-Shun,Zu, Wen-Biao,Zhu, Yan-Yan,et al. Siegesoxylipin A-J, previously undescribed phyto-oxylipins inhibition of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci from Sigesbeckia orientalis[J]. PHYTOCHEMISTRY,2025,231:114355.
APA	Zhou, Zhong-Shun.,Zu, Wen-Biao.,Zhu, Yan-Yan.,Wei, Mei-Zhen.,Jiang, Yue-Ming.,...&Luo, Xiao-Dong.(2025).Siegesoxylipin A-J, previously undescribed phyto-oxylipins inhibition of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci from Sigesbeckia orientalis.PHYTOCHEMISTRY,231,114355.
MLA	Zhou, Zhong-Shun,et al."Siegesoxylipin A-J, previously undescribed phyto-oxylipins inhibition of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci from Sigesbeckia orientalis".PHYTOCHEMISTRY 231(2025):114355.

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