Structurally Diverse Limonoids from Trichilia connaroides and Their Antitumor Activities

doi:10.1002/cjoc.202400923

KIB OpenIR

	Structurally Diverse Limonoids from Trichilia connaroides and Their Antitumor Activities
	Yan, Ying; Wang, Dan; Zhou, Fang-Jiao; Zhao, Yu-Han; Qin, Xu-Jie; Zhang, Yu; Ding, Xiao; Hao, Xiao-Jiang
	2024
发表期刊	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
卷号	42 期号:24 页码:3567-3580
摘要	Twelve new limonoids (1-12), named trichilitins A-L, were isolated from the leaves and twigs of Trichilia connaroides, together with ten known compounds (13-22). The structures were elucidated by extensive spectroscopic investigations, X-ray diffraction analyses, and ECD calculations. Compound 1, which belongs to a unique class of ring B-seco limonoid, has been identified as 6/7/6/5 tetracyclic due to a key Baeyer-Villiger oxidation. Compounds 2-7 were identified as ring intact limonoids, while compounds 8-10 were established as ring D-seco ones, and 11 and 12 were determined to be rearranged ones. All of the compounds were tested for cytotoxicity against three human tumor cell lines (HCT-116, NCl-H1975, and SH-SY5Y). Compounds 6, 7, 13, 14, and 19 exhibited significant cytotoxic effects, especially 7 exhibited significant cytotoxic effects against HCT-116 with an IC50 value of 0.035 mu molL-1 and was more active than the positive control, doxorubicin with an IC50 value of 0.20 mu molL-1. Compound 7 effectively induced apoptosis of HCT-116, which was associated with S-phase cell cycle arrest. Furthermore, the Western blot analysis showed that compound 7 could induce cell cycle arrest by promoting the expression levels of p53 and p21.
DOI	10.1002/cjoc.202400923
WOS记录号	WOS:001357330100001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76196
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yan, Ying,Wang, Dan,Zhou, Fang-Jiao,et al. Structurally Diverse Limonoids from Trichilia connaroides and Their Antitumor Activities[J]. CHINESE JOURNAL OF CHEMISTRY,2024,42(24):3567-3580.
APA	Yan, Ying.,Wang, Dan.,Zhou, Fang-Jiao.,Zhao, Yu-Han.,Qin, Xu-Jie.,...&Hao, Xiao-Jiang.(2024).Structurally Diverse Limonoids from Trichilia connaroides and Their Antitumor Activities.CHINESE JOURNAL OF CHEMISTRY,42(24),3567-3580.
MLA	Yan, Ying,et al."Structurally Diverse Limonoids from Trichilia connaroides and Their Antitumor Activities".CHINESE JOURNAL OF CHEMISTRY 42.24(2024):3567-3580.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1002_cjoc.2024009（3892KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载