Structural analysis and accelerating wound healing function of a novel galactosylated glycosaminoglycan from the snail Helix lucorum

doi:10.1016/j.carbpol.2024.122900

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	Structural analysis and accelerating wound healing function of a novel galactosylated glycosaminoglycan from the snail Helix lucorum
	Li, Ya; Wang, Xingzi; Chen, Jiangyan; Sun, Luyun; Pu, Debing; Lin, Lisha; Luo, Lan; Gong, Xi; Pu, Junxue; Wu, Mingyi
	2025
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	348 页码:122900
摘要	Diabetic foot ulcers (DFUs) as a nonhealing wound remain a clinical challenge, and the development of prohealing and cost-effective drugs is in urgent need. Herein, we reported a novel galactosylated glycosaminoglycan (GAG) from the snail Helix lucorum, as an effective pro-healing compound. The snail GAG is composed of a heparan sulfate-like main chain and galactose side chains at C-3 of GlcNAc residue. Its main chain has a repeating disaccharide structure of -* 4)-alpha-D-GlcNAc-(1 -* 4)-alpha-L-IdoA2S(1 -*. This is the first example of glycosaminoglycan with galactose branches from mollusks. Pharmacological experiments showed that the H. lucorum GAG significantly promoted skin wound healing in both healthy and diabetic mice by accelerating granulation tissue regeneration, angiogenesis, and collagen deposition. The distinctive galactosylated substitution may play an important role on its pro-healing activity. Our discovery enriches the diversity of non-anticoagulant heparan sulfate-like glycosaminoglycans, and provides a potential candidate of pro-healing drug for treating diabetic wound.
DOI	10.1016/j.carbpol.2024.122900
WOS记录号	WOS:001344527400001
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76190
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Li, Ya,Wang, Xingzi,Chen, Jiangyan,et al. Structural analysis and accelerating wound healing function of a novel galactosylated glycosaminoglycan from the snail Helix lucorum[J]. CARBOHYDRATE POLYMERS,2025,348:122900.
APA	Li, Ya.,Wang, Xingzi.,Chen, Jiangyan.,Sun, Luyun.,Pu, Debing.,...&Wu, Mingyi.(2025).Structural analysis and accelerating wound healing function of a novel galactosylated glycosaminoglycan from the snail Helix lucorum.CARBOHYDRATE POLYMERS,348,122900.
MLA	Li, Ya,et al."Structural analysis and accelerating wound healing function of a novel galactosylated glycosaminoglycan from the snail Helix lucorum".CARBOHYDRATE POLYMERS 348(2025):122900.

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