Hyperkouytones A-O, New Polyprenylated Acylphloroglucinols from Hypericum kouytchense with Multidrug Resistance Reversal Activity

doi:10.1002/cjoc.202400739

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	Hyperkouytones A-O, New Polyprenylated Acylphloroglucinols from Hypericum kouytchense with Multidrug Resistance Reversal Activity
	Lou, Hua-Yong; Chen, Mei-Jun; Yi, Ping; Jin, Jun; Zeng, Yan-Rong; Gu, Wei; Hu, Zhan-Xing; Yang, Jue; Hao, Xiao-Jiang; Yuan, Chun-Mao
	2024
发表期刊	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
卷号	42 期号:24 页码:3293-3307
摘要	Given the lack of systematic polyprenylated acylphloroglucinols (PPAPs) research on traditional Chinese medicine of Hypericum kouytchense, this plant was applied for the phytochemical study, which led to fifteen new PPAPs (1-15, PPAPs), along with 36 known PPAP derivatives. Their structures and absolute configurations were established by comprehensive spectral analysis and theoretical ECD and NMR calculations. Structurally, compound 1 possesses a rare fused 6/6/6/5/5 pentacyclic ring system. Eleven compounds exhibited good multidrug resistance reversal activity (RF ranging from 5 to 53) in HepG2/ADR cells. Importantly, compound 34, the most potential MDR modulator, showed better reversal effect (RF: 53) than positive control, verapamil. The primary mechanistic study of compound 34, implied that this compound could prohibit the function of P-gp transport rather than its expression. The possible recognition mechanism between compound 34 and P-gp was predicted by molecular docking.
DOI	10.1002/cjoc.202400739
WOS记录号	WOS:001303997900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76169
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Lou, Hua-Yong,Chen, Mei-Jun,Yi, Ping,et al. Hyperkouytones A-O, New Polyprenylated Acylphloroglucinols from Hypericum kouytchense with Multidrug Resistance Reversal Activity[J]. CHINESE JOURNAL OF CHEMISTRY,2024,42(24):3293-3307.
APA	Lou, Hua-Yong.,Chen, Mei-Jun.,Yi, Ping.,Jin, Jun.,Zeng, Yan-Rong.,...&Yuan, Chun-Mao.(2024).Hyperkouytones A-O, New Polyprenylated Acylphloroglucinols from Hypericum kouytchense with Multidrug Resistance Reversal Activity.CHINESE JOURNAL OF CHEMISTRY,42(24),3293-3307.
MLA	Lou, Hua-Yong,et al."Hyperkouytones A-O, New Polyprenylated Acylphloroglucinols from Hypericum kouytchense with Multidrug Resistance Reversal Activity".CHINESE JOURNAL OF CHEMISTRY 42.24(2024):3293-3307.

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