Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity.

doi:10.1007/s13659-024-00428-0

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	Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity.
	Qin, Shihui; Li, Yanlang; Shao, Huiyan; Yu, Yang; Yang, Yina; Zeng, Yi; Huang, Jia; Hu, Jiang-Miao; Yang, Liu
	2024
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	14 期号:1 页码:10-10
摘要	As the two most principal active substances in the corn silk, polysaccharides and flavonoids, the mechanism of interaction between them has been a topic of intense research. This study provides an in-depth investigation of the interaction mechanism between corn silk glycans and luteoloside (LUT) and the synergistic role that result from this interaction. The interaction mechanism was evaluated by isothermal titration calorimetry (ITC) and circular dichroism (CD), and the synergistic role was evaluated by the expression of glucose transporters (GLUT-1), insulin secretion and surface plasmon resonance (SPR). CD and ITC results indicated that the interaction between CSGs and LUT mainly driven by the Cotton effects, enthalpy and entropy-driven. This interaction precipitated the formation of complexes (CSGs/LUT complexes) between corn silk glycans (CSGs) with four different molecular weights and luteoloside (LUT). Furthermore, the CSGs and LUT play a synergistic role in glucose regulation through GLUT-1 expression and insulin secretion experiments, compared to single luteoloside group.
DOI	10.1007/s13659-024-00428-0
WOS记录号	MEDLINE:38225526
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76124
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Qin, Shihui,Li, Yanlang,Shao, Huiyan,et al. Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity.[J]. Natural products and bioprospecting,2024,14(1):10-10.
APA	Qin, Shihui.,Li, Yanlang.,Shao, Huiyan.,Yu, Yang.,Yang, Yina.,...&Yang, Liu.(2024).Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity..Natural products and bioprospecting,14(1),10-10.
MLA	Qin, Shihui,et al."Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity.".Natural products and bioprospecting 14.1(2024):10-10.

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