Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of beta-catenin.

doi:10.1007/s13659-024-00443-1

KIB OpenIR

	Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of beta-catenin.
	Su, Guifeng; Wang, Dan; Yang, Qianqing; Kong, Lingmei; Ju, Xiaoman; Yang, Qihong; Zhu, Yiying; Zhang, Shaohua; Li, Yan
	2024
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	14 期号:1 页码:18-18
摘要	The aberrant activation of the Wnt/beta-catenin signaling pathway is closely associated with the development of various carcinomas, especially colorectal cancers (CRCs), where adenomatous colorectal polyposis (APC) mutations are the most frequently observed, which limits the anti-tumor efficiency of inhibitors targeting the upstream of Wnt/beta-catenin pathway. The anti-tumor activity of the naturally occurring alkaloid cepharanthine (CEP) extracted from the plant Stephania cepharantha Hayata has been reported in various types of tumors. We previously observed that its derivatives inhibited the Wnt/beta-catenin signaling in liver cancer; however, the specific mechanism remains unknown. In this study, we confirmed CEP can effectively inhibit APC-mutant CRC cell lines (SW480, SW620, LoVo) through disturbing of the Wnt/beta-catenin signaling and elucidated the underlying mechanisms. Here, we demonstrate that CEP attenuates the Wnt/beta-catenin signaling by decreasing the beta-catenin, subsequently impeding the proliferation of APC-mutant CRCs. Moreover, CEP induced beta-catenin transcription inhibition rather than the instability of beta-catenin protein and mRNA contributes to reduction of beta-catenin. Taken together, our findings identify CEP as the first beta-catenin transcriptional inhibitor in the modulation of Wnt/beta-catenin signaling and indicate CEP as a potential therapeutic option for the treatment of APC-mutated CRCs.
DOI	10.1007/s13659-024-00443-1
WOS记录号	MEDLINE:38421454
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76122
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Su, Guifeng,Wang, Dan,Yang, Qianqing,et al. Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of beta-catenin.[J]. Natural products and bioprospecting,2024,14(1):18-18.
APA	Su, Guifeng.,Wang, Dan.,Yang, Qianqing.,Kong, Lingmei.,Ju, Xiaoman.,...&Li, Yan.(2024).Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of beta-catenin..Natural products and bioprospecting,14(1),18-18.
MLA	Su, Guifeng,et al."Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of beta-catenin.".Natural products and bioprospecting 14.1(2024):18-18.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1007_s13659-024-0（3377KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览请求全文