Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-kappaB signaling pathway.

doi:10.1007/s13659-024-00458-8

KIB OpenIR

	Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-kappaB signaling pathway.
	Shi, Yuru; Zhang, Xiaoqian; Pei, Shengji; Wang, Yuhua
	2024
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	14 期号:1 页码:36-36
摘要	Adenosma buchneroides Bonati, also known as fleagrass, is an important medicinal plant used by the Akha (Hani) people of China for treating inflammation-related skin swelling, acne, and diarrhoea, among other conditions. In this study, we aimed to evaluate the anti-inflammatory activities and explore the molecular mechanisms of fleagrass on treating skin swelling and acne. The results demonstrated that fleagrass inhibited the enzymatic activities of 5-LOX and COX-2 in vitro, and decreased the release of NO, IL-6, TNF-alpha, and IL-10 in the LPS-induced RAW264.7 macrophages. The levels of proteins associated with the nuclear factor-kappa B (NF-kappaB) pathway were examined by western blotting and immunofluorescence, demonstrating that fleagrass downregulated the expression of TLR4, MyD88, NF-kappaB/p65, and iNOS and blocked the nuclear translocation of NF-kappaB/p65. Furthermore, fleagrass exhibited acute anti-inflammatory activity in paw oedema models. The results confirm that fleagrass exhibits remarkable anti-inflammatory activity and can be used in alleviating inflammation, suggesting that fleagrass has the potential to be a novel anti-inflammatory agent.
DOI	10.1007/s13659-024-00458-8
WOS记录号	MEDLINE:38833115
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76119
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Shi, Yuru,Zhang, Xiaoqian,Pei, Shengji,et al. Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-kappaB signaling pathway.[J]. Natural products and bioprospecting,2024,14(1):36-36.
APA	Shi, Yuru,Zhang, Xiaoqian,Pei, Shengji,&Wang, Yuhua.(2024).Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-kappaB signaling pathway..Natural products and bioprospecting,14(1),36-36.
MLA	Shi, Yuru,et al."Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-kappaB signaling pathway.".Natural products and bioprospecting 14.1(2024):36-36.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1007_s13659-024-0（3282KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载