A natural acylphloroglucinol exerts anti-erythroleukemia effects via targeting STAT3 and p38-MAPK, and inhibiting PI3K/AKT/mTOR signaling pathway

doi:10.1016/j.biopha.2024.117424

KIB OpenIR

	A natural acylphloroglucinol exerts anti-erythroleukemia effects via targeting STAT3 and p38-MAPK, and inhibiting PI3K/AKT/mTOR signaling pathway
	Song, Jing-Rui; Niu, Zhen-Peng; Yang, Kun; Wang, Li; Huang, Yu-Bing; Rao, Qing; Liu, Hai-Yang; Hao, Xiao-Jiang; Li, Yan-Mei
	2024
发表期刊	BIOMEDICINE & PHARMACOTHERAPY
ISSN	0753-3322
卷号	180 页码:117424
摘要	Erythroleukemia, a subtype of acute myeloid leukemia (AML), is a life-threatening malignancy that affects the blood and bone marrow. Despite the availability of clinical treatments, the complex pathogenesis of the disease and the severe side effects of chemotherapy continue to impede therapeutic progress in leukemia. In this study, we investigated the antitumor activity of L76, an acylphloroglucinol compound derived from Callistemon salignus DC., against erythroleukemia, along with its underlying mechanisms. MTT assays were performed to evaluate the inhibitory effects of L76 on cancer cell viability, while flow cytometry was used to analyze apoptosis and cell cycle arrest in HEL cells. The molecular mechanisms of L76 were further explored using Western blotting, microscopic analysis, and cellular thermal shift assays (CETSA). Our in vitro experiments demonstrated that L76 inhibits proliferation, induces G1/S cell cycle arrest, and promotes apoptosis in human leukemia cells. Mechanistically, L76 exerts its effects by targeting STAT3 and p38-MAPK, and by inhibiting the PI3K/AKT/mTOR signaling pathway. In conclusion, this study highlights the potential of L76 as an anti-erythroleukemia agent, demonstrating its ability to target STAT3 and p38-MAPK, and to inhibit the PI3K/AKT/mTOR signaling pathway. These findings suggest that L76 could be a promising candidate for the treatment of erythroleukemia.
DOI	10.1016/j.biopha.2024.117424
WOS记录号	WOS:001319636500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76110
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Song, Jing-Rui,Niu, Zhen-Peng,Yang, Kun,et al. A natural acylphloroglucinol exerts anti-erythroleukemia effects via targeting STAT3 and p38-MAPK, and inhibiting PI3K/AKT/mTOR signaling pathway[J]. BIOMEDICINE & PHARMACOTHERAPY,2024,180:117424.
APA	Song, Jing-Rui.,Niu, Zhen-Peng.,Yang, Kun.,Wang, Li.,Huang, Yu-Bing.,...&Li, Yan-Mei.(2024).A natural acylphloroglucinol exerts anti-erythroleukemia effects via targeting STAT3 and p38-MAPK, and inhibiting PI3K/AKT/mTOR signaling pathway.BIOMEDICINE & PHARMACOTHERAPY,180,117424.
MLA	Song, Jing-Rui,et al."A natural acylphloroglucinol exerts anti-erythroleukemia effects via targeting STAT3 and p38-MAPK, and inhibiting PI3K/AKT/mTOR signaling pathway".BIOMEDICINE & PHARMACOTHERAPY 180(2024):117424.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1016_j.biopha.202（9275KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载