Bionic sulfated glycosaminoglycan-based hydrogel inspired by snail mucus promotes diabetic chronic wound healing via regulating macrophage polarization

doi:10.1016/j.ijbiomac.2024.135708

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	Bionic sulfated glycosaminoglycan-based hydrogel inspired by snail mucus promotes diabetic chronic wound healing via regulating macrophage polarization
	Sun, Luyun; Wang, Xingzi; Deng, Tuo; Luo, Lan; Lin, Lisha; Yang, Lian; Tian, Yong; Tian, Yuncai; Wu, Mingyi
	2024
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	281 页码:135708
摘要	The treatment of diabetic foot ulcers remains a significant challenge, as their morbidity is increasing while current therapies are expensive and often ineffective. The dried mucus from the snail Achatina fulica promotes diabetic wound healing. Herein, to develop a more controllable and stable wound dressing for diabetic wound treatment, the AFG/StarPEG hydrogel mimicking snail mucus was prepared by covalently coupling of sulfated glycosaminoglycan from A. fulica (AFG) with star-shaped polyethylene glycol (StarPEG) amine. The AFG/StarPEG hydrogel reduced excessive inflammation in wound tissues by decreasing pro-inflammatory cytokines (IL-6, IL-1 beta, and TNF-alpha) and increasing anti-inflammatory cytokines (IL-4 and IL-10). Moreover, it promoted the polarization of macrophages to M2 anti-inflammatory type in diabetic wound. By improving transition of diabetic chronic wound from inflammatory phase to proliferative phase, it promoted angiogenesis, collagen deposition and re-epithelialization, and thus tissue regeneration for wound healing. This work provides a convenient and effective dressing for treating chronic diabetic wound.
DOI	10.1016/j.ijbiomac.2024.135708
WOS记录号	WOS:001356979600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76080
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Sun, Luyun,Wang, Xingzi,Deng, Tuo,et al. Bionic sulfated glycosaminoglycan-based hydrogel inspired by snail mucus promotes diabetic chronic wound healing via regulating macrophage polarization[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,281:135708.
APA	Sun, Luyun.,Wang, Xingzi.,Deng, Tuo.,Luo, Lan.,Lin, Lisha.,...&Wu, Mingyi.(2024).Bionic sulfated glycosaminoglycan-based hydrogel inspired by snail mucus promotes diabetic chronic wound healing via regulating macrophage polarization.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,281,135708.
MLA	Sun, Luyun,et al."Bionic sulfated glycosaminoglycan-based hydrogel inspired by snail mucus promotes diabetic chronic wound healing via regulating macrophage polarization".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 281(2024):135708.

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