Unusual cadinane-involved sesquiterpenoid dimers from Artemisia annua and their antihepatoma effect

doi:10.1016/j.phytochem.2024.114216

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	Unusual cadinane-involved sesquiterpenoid dimers from Artemisia annua and their antihepatoma effect
	He, Xiao-Feng; Li, Tian-Ze; Ma, Yun-Bao; Wang, Meng-Fei; Chen, Ji-Jun
	2024
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	226 页码:114216
摘要	Artemisia annua L. (Qinghao in Chinese) is a famous traditional Chinese medicinal herb and has been used to treat malaria and various tumors. Our preliminary screening indicated that the EtOAc extract of A. annua manifested activity against HepG2, Huh7, and SK-Hep-1 cell lines with inhibitory ratios of 53.2%, 52.1%, and 59.6% at 200 mu g/mL, respectively. Bioassay-guided isolation of A. annua afforded 14 unusual cadinane-involved sesquiterpenoid dimers, artemannuins A-N (1-14), of which the structures were elucidated by extensive spectral analyses, ECD calculations, and single-crystal X-ray diffraction. Structurally, these compounds were classified into five different types based on the coupled modes of two monomeric sesquiterpenoids. Among them, compounds 1-9 represented the first examples of sesquiterpenoid dimers formed via the C-3-C-3 ' single bond of two 5(4 -> 3)-abeo-cadinane sesquiterpenoid monomers, while compounds 13 and 14 were dimers fused by cadinane and humulane sesquiterpenoids via an ester bond. Methylated derivatives of 1, 4, 6, and 8 showed antihepatoma activity against HepG2, Huh7, and SK-Hep-1 cell lines with IC50 values ranging from 30.5 to 57.2 mu M.
DOI	10.1016/j.phytochem.2024.114216
WOS记录号	WOS:001267918700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76061
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	He, Xiao-Feng,Li, Tian-Ze,Ma, Yun-Bao,et al. Unusual cadinane-involved sesquiterpenoid dimers from Artemisia annua and their antihepatoma effect[J]. PHYTOCHEMISTRY,2024,226:114216.
APA	He, Xiao-Feng,Li, Tian-Ze,Ma, Yun-Bao,Wang, Meng-Fei,&Chen, Ji-Jun.(2024).Unusual cadinane-involved sesquiterpenoid dimers from Artemisia annua and their antihepatoma effect.PHYTOCHEMISTRY,226,114216.
MLA	He, Xiao-Feng,et al."Unusual cadinane-involved sesquiterpenoid dimers from Artemisia annua and their antihepatoma effect".PHYTOCHEMISTRY 226(2024):114216.

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