Acetylcholinesterase inhibitory phloroglucinols from tropic Rhodomyrtus tomentosa

doi:10.1016/j.phytochem.2024.114254

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	Acetylcholinesterase inhibitory phloroglucinols from tropic Rhodomyrtus tomentosa
	Chen, Ling-Yun; Luo, E. -e; Pan, Yu; Liang, Cheng-Qin; Yu, Mu-Yuan; Qin, Xu-Jie
	2024
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	228 页码:114254
摘要	Four previously undescribed phloroglucinols, including three pairs of enantiomers, (f)-rhodotomentodimer F, (f)-rhodotomentodimer G, and (f)-rhodotomentomonomer E, and one phloroglucinol-sesquiterpene meroterpenoid, rhodotomentodione E, together with one previously reported congener, (f)-rhodomyrtosone A, were obtained from the leaves of Rhodomyrtus tomentosa. The structures including absolute configurations of previously undescribed isolates were elucidated by extensive spectroscopic analysis (HRESIMS and NMR), ECD calculations, and single-crystal X-ray diffraction. (f)-Rhodotomentodimer F is a rare phloroglucinol derivative conjugated by a /3-triketone moiety and an unprecedented resorcinol unit via the formation of a rare bis-furan ring system, whereas (f)-rhodotomentomonomer E shares a rearranged pentacyclic scaffold. Pharmacologically, (f)-rhodotomentomonomer E showed the strongest human acetylcholinesterase (hAChE) inhibitory effect with an IC50 value of 1.04 f 0.05 mu M. Molecular formula studies revealed that hydrogen bonds formed between hAChE residues Glu202, Ser203, Ala204, Gly121, Gly122, Tyr337, and His447 and (f)-rhodotomentomonomer E played crucial roles in its observed activity. These findings indicated that the leaves of Rhodomyrtus tomentosa can supply a rich source of hAChE inhibitors. These inhibitors might potentially be utilized in the therapeutic strategy for Alzheimer's disease, offering promising candidates for further research and development.
DOI	10.1016/j.phytochem.2024.114254
WOS记录号	WOS:001301351600001
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76058
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Chen, Ling-Yun,Luo, E. -e,Pan, Yu,et al. Acetylcholinesterase inhibitory phloroglucinols from tropic Rhodomyrtus tomentosa[J]. PHYTOCHEMISTRY,2024,228:114254.
APA	Chen, Ling-Yun,Luo, E. -e,Pan, Yu,Liang, Cheng-Qin,Yu, Mu-Yuan,&Qin, Xu-Jie.(2024).Acetylcholinesterase inhibitory phloroglucinols from tropic Rhodomyrtus tomentosa.PHYTOCHEMISTRY,228,114254.
MLA	Chen, Ling-Yun,et al."Acetylcholinesterase inhibitory phloroglucinols from tropic Rhodomyrtus tomentosa".PHYTOCHEMISTRY 228(2024):114254.

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