Cytotoxic steroidal glycosides from Paris rugosa rhizomes

doi:10.1016/j.phytol.2024.07.011

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	Cytotoxic steroidal glycosides from Paris rugosa rhizomes
	Jia, Jian-Ke; Yang, Jun; Yang, Xing-Zhi; Luo, Ji-Feng; Duan, Xiao-Yan; Yang, Ying-Li; Wan, Jin-Fu; Wang, Yue-Hu
	2024
发表期刊	PHYTOCHEMISTRY LETTERS
ISSN	1874-3900
卷号	63 页码:1-7
摘要	Two previously undescribed steroidal saponins, rugosarosides A (1) and B (2), as well as 16 known compounds (3-18), were isolated from the rhizomes of Paris rugosa H. Li & S. Kurita (Melanthiaceae). Their chemical structures were elucidated based on extensive analyses of NMR and MS data and acidic hydrolyses. These isolates were evaluated for their cytotoxicity to five human cancer cell lines (HL-60, SW480, MDA-MB-231, A549, and A549/Taxol) and the normal human bronchial epithelial cell line BEAS-2B using the MTS test. Spirostanol saponins 6-12 and furostanol saponin 16 showed cytotoxic activity, with IC50 values ranging from 0.13 to 3.88 mu M. The furostanol saponins 14, 15, and 17 selectively inhibited HL-60, A549, and A549/Taxol cells (IC50: 3.45-9.51 mu M), with no cytotoxicity to SW480 and MDA-MB-231 cells (IC50 > 40 mu M).
DOI	10.1016/j.phytol.2024.07.011
WOS记录号	WOS:001282002600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76057
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Jia, Jian-Ke,Yang, Jun,Yang, Xing-Zhi,et al. Cytotoxic steroidal glycosides from Paris rugosa rhizomes[J]. PHYTOCHEMISTRY LETTERS,2024,63:1-7.
APA	Jia, Jian-Ke.,Yang, Jun.,Yang, Xing-Zhi.,Luo, Ji-Feng.,Duan, Xiao-Yan.,...&Wang, Yue-Hu.(2024).Cytotoxic steroidal glycosides from Paris rugosa rhizomes.PHYTOCHEMISTRY LETTERS,63,1-7.
MLA	Jia, Jian-Ke,et al."Cytotoxic steroidal glycosides from Paris rugosa rhizomes".PHYTOCHEMISTRY LETTERS 63(2024):1-7.

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