Activity of the Caged Xanthone Morellic Acid against Vancomycin-Resistant Enterococcus Infection by Targeting the Bacterial Membrane

doi:10.1021/acs.jnatprod.4c00425

KIB OpenIR

	Activity of the Caged Xanthone Morellic Acid against Vancomycin-Resistant Enterococcus Infection by Targeting the Bacterial Membrane
	Tang, Dong-Mei; Wang, Zhao-Jie; Zu, Wen-Biao; Jiang, Yue-Ming; Zhu, Yan-Yan; Wei, Mei-Zhen; Luo, Xiao-Dong
	2024
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	87 期号:10 页码:2366-2375
摘要	Vancomycin-resistant Enterococcus (VRE) is an important nosocomial opportunistic pathogen that is associated with multidrug resistance. Here, we demonstrate that morellic acid inhibits VRE by restoring its sensitivity to vancomycin and ampicillin with low drug resistance and efficient biofilm clearance effects. Morellic acid binds to inner membrane phospholipids, such as phosphatidylethanolamine (PE), phosphatidylglycerol (PG), and cardiolipin (CL) of VRE, such that the fluidity and proton-motive force (PMF) interfere with the damaged inner membrane, causing intracellular reactive oxygen species (ROS) accumulation and bacterial death. Transcriptional analyses supported this effect on inner membrane-related pathways such as fatty acid biosynthesis and glycerophospholipid metabolism. Moreover, morellic acid significantly eliminated residual bacteria in the spleen, liver, kidneys, and abdominal effusion in mice. Our findings indicate the potential applications of morellic acid as an antibacterial agent or adjuvant for treating VRE infections.
DOI	10.1021/acs.jnatprod.4c00425
WOS记录号	WOS:001336900600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76014
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Tang, Dong-Mei,Wang, Zhao-Jie,Zu, Wen-Biao,et al. Activity of the Caged Xanthone Morellic Acid against Vancomycin-Resistant Enterococcus Infection by Targeting the Bacterial Membrane[J]. JOURNAL OF NATURAL PRODUCTS,2024,87(10):2366-2375.
APA	Tang, Dong-Mei.,Wang, Zhao-Jie.,Zu, Wen-Biao.,Jiang, Yue-Ming.,Zhu, Yan-Yan.,...&Luo, Xiao-Dong.(2024).Activity of the Caged Xanthone Morellic Acid against Vancomycin-Resistant Enterococcus Infection by Targeting the Bacterial Membrane.JOURNAL OF NATURAL PRODUCTS,87(10),2366-2375.
MLA	Tang, Dong-Mei,et al."Activity of the Caged Xanthone Morellic Acid against Vancomycin-Resistant Enterococcus Infection by Targeting the Bacterial Membrane".JOURNAL OF NATURAL PRODUCTS 87.10(2024):2366-2375.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1021_acs.jnatprod（9511KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载