Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes.

doi:10.1021/jacsau.3c00748

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	Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes.
	Nieto-Fabregat, Ferran; Zhu, Qian; Vives, Corinne; Zhang, Yunqin; Marseglia, Angela; Chiodo, Fabrizio; Thepaut, Michel; Rai, Diksha; Kulkarni, Suvarn S; Di Lorenzo, Flaviana; Molinaro, Antonio; Marchetti, Roberta; Fieschi, Franck; Xiao, Guozhi; Yu, Biao; Silipo, Alba
	2024
发表期刊	JACS Au
卷号	4 期号:2 页码:697-712
摘要	The evaluation of Bacteroides vulgatus mpk (BVMPK) lipopolysaccharide (LPS) recognition by DC-SIGN, a key lectin in mediating immune homeostasis, has been here performed. A fine chemical dissection of BVMPK LPS components, attained by synthetic chemistry combined to spectroscopic, biophysical, and computational techniques, allowed to finely map the LPS epitopes recognized by DC-SIGN. Our findings reveal BVMPK's role in immune modulation via DC-SIGN, targeting both the LPS O-antigen and the core oligosaccharide. Furthermore, when framed within medical chemistry or drug design, our results could lead to the development of tailored molecules to benefit the hosts dealing with inflammatory diseases.
DOI	10.1021/jacsau.3c00748
WOS记录号	MEDLINE:38425910
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76006
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Nieto-Fabregat, Ferran,Zhu, Qian,Vives, Corinne,et al. Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes.[J]. JACS Au,2024,4(2):697-712.
APA	Nieto-Fabregat, Ferran.,Zhu, Qian.,Vives, Corinne.,Zhang, Yunqin.,Marseglia, Angela.,...&Silipo, Alba.(2024).Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes..JACS Au,4(2),697-712.
MLA	Nieto-Fabregat, Ferran,et al."Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes.".JACS Au 4.2(2024):697-712.

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