Three New Ent-Kaurane Diterpenes with Antibacterial Activity from Sigesbeckia orientalis

doi:10.3390/molecules29194631

KIB OpenIR

	Three New Ent-Kaurane Diterpenes with Antibacterial Activity from Sigesbeckia orientalis
	Zhou, Zhong-Shun; Wang, Zhao-Jie; Tian, Bei; Zhu, Yan-Yan; Wei, Mei-Zhen; Zhao, Yun-Li; Luo, Xiao-Dong
	2024
发表期刊	MOLECULES
卷号	29 期号:19 页码:4631
摘要	Three novel ent-kaurane diterpenes, namely sigesbeckin A-C (1-3), in conjunction with eight previously identified analogues (4-11), were isolated from Sigesbeckia orientalis. Their chemical structures were resolved through multiple spectroscopic analyses. All compounds were assessed for antimicrobial bioactivity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) strains. In particular, compounds 1 and 5 demonstrated moderate efficacy, with MIC values of 64 mu g/mL. Moreover, compounds 3, 5, and 11 were found to synergize with doxorubicin hydrochloride (DOX) and vancomycin (VAN) against MRSA and VRE. The aforementioned findings offer valuable insights for the development of novel alternatives to antibiotics, which can effectively tackle the escalating issue of antibiotic resistance.
DOI	10.3390/molecules29194631
WOS记录号	WOS:001334396600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75774
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhou, Zhong-Shun,Wang, Zhao-Jie,Tian, Bei,et al. Three New Ent-Kaurane Diterpenes with Antibacterial Activity from Sigesbeckia orientalis[J]. MOLECULES,2024,29(19):4631.
APA	Zhou, Zhong-Shun.,Wang, Zhao-Jie.,Tian, Bei.,Zhu, Yan-Yan.,Wei, Mei-Zhen.,...&Luo, Xiao-Dong.(2024).Three New Ent-Kaurane Diterpenes with Antibacterial Activity from Sigesbeckia orientalis.MOLECULES,29(19),4631.
MLA	Zhou, Zhong-Shun,et al."Three New Ent-Kaurane Diterpenes with Antibacterial Activity from Sigesbeckia orientalis".MOLECULES 29.19(2024):4631.

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