Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A

doi:10.6023/cjoc202401017

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	Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A
	Yang Shuai; Wu Jie; Wang Liangliang
	2024
发表期刊	CHINESE JOURNAL OF ORGANIC CHEMISTRY
ISSN	0253-2786
卷号	44 期号:7 页码:2350-2362
摘要	Natural product elansolid A belongs to one type of polyketide macrolactone with promising antibiotic activity. Previously, the first total synthesis of elansolid A in 28 longest linear sequence (LLS) and 41 steps in total has been achieved. Herein, the simplified analog of elansolid A, featured with a cyclohexyl-fused 19-memebered macrolactone, was proposed, and its asymmetric total synthesis based on a convergent strategy and key reactions exemplified by desymmetric alcoholysis of anhydride, Pd-catalyzed Stille coupling, Suzuki-Miyaura coupling as well as Mukaiyama macrolactonization was finished.
DOI	10.6023/cjoc202401017
WOS记录号	WOS:001282088700023
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75728
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yang Shuai,Wu Jie,Wang Liangliang. Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2024,44(7):2350-2362.
APA	Yang Shuai,Wu Jie,&Wang Liangliang.(2024).Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A.CHINESE JOURNAL OF ORGANIC CHEMISTRY,44(7),2350-2362.
MLA	Yang Shuai,et al."Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A".CHINESE JOURNAL OF ORGANIC CHEMISTRY 44.7(2024):2350-2362.

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