Two Novel Phenylpropanoid Trimers From Ligusticum chuanxiong Hort With Inhibitory Activities on Alpha-Hemolysin Secreted by Staphylococcus aureus

doi:10.3389/fchem.2022.877469

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	Two Novel Phenylpropanoid Trimers From Ligusticum chuanxiong Hort With Inhibitory Activities on Alpha-Hemolysin Secreted by Staphylococcus aureus
	Wan, Shi-Jie; Ren, Han-Gui; Jiang, Jia-Ming; Xu, Gang; Xu, Yu; Chen, Si-Min; Chen, Gan; Zheng, Dan; Yuan, Man; Zhang, Hong; Xu, Hong-Xi
	2022
发表期刊	FRONTIERS IN CHEMISTRY
卷号	10 页码:877469
摘要	The emergence of antibiotic resistance in Staphylococcus aureus has necessitated the development of innovative anti-infective agents acting on novel targets. Alpha-hemolysin (Hla), a key virulence factor of S. aureus, is known to cause various cell damage and death. In this study, with bioassay-guided fractionation, a pair of unusual epimeric lignan trimers, ligustchuanes A and B (1 and 2), were isolated from the rhizomes of Ligusticum chuanxiong Hort, together with two known phthalides being identified by UPLC-QTOF-MS. To the best of our knowledge, trimers with rare C8-C9-type neolignan and ferulic acid fragments have not been identified in any natural product. Both of them were isolated as racemic mixtures, and their absolute configurations were determined by comparing experimental and calculated ECD spectra after enantioseparation. Ligustchuane B exhibited an outstanding inhibitory effect on alpha-hemolysin expression in both MRSA USA300 LAC and MSSA Newman strains at concentrations of 3 and 6 mu M, respectively. Notably, a mouse model of infection further demonstrated that ligustchuane B could attenuate MRSA virulence in vivo.
关键词	Staphylococcus aureus alpha-hemolysin Ligusticum chuanxiong Hort lignan anti-virulence VIRULENCE DERIVATIVES DISCOVERY TOXIN
DOI	10.3389/fchem.2022.877469
收录类别	SCI
WOS记录号	WOS:000821331400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75656
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wan, Shi-Jie,Ren, Han-Gui,Jiang, Jia-Ming,et al. Two Novel Phenylpropanoid Trimers From Ligusticum chuanxiong Hort With Inhibitory Activities on Alpha-Hemolysin Secreted by Staphylococcus aureus[J]. FRONTIERS IN CHEMISTRY,2022,10:877469.
APA	Wan, Shi-Jie.,Ren, Han-Gui.,Jiang, Jia-Ming.,Xu, Gang.,Xu, Yu.,...&Xu, Hong-Xi.(2022).Two Novel Phenylpropanoid Trimers From Ligusticum chuanxiong Hort With Inhibitory Activities on Alpha-Hemolysin Secreted by Staphylococcus aureus.FRONTIERS IN CHEMISTRY,10,877469.
MLA	Wan, Shi-Jie,et al."Two Novel Phenylpropanoid Trimers From Ligusticum chuanxiong Hort With Inhibitory Activities on Alpha-Hemolysin Secreted by Staphylococcus aureus".FRONTIERS IN CHEMISTRY 10(2022):877469.

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