Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3

doi:10.3389/fchem.2022.950726

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	Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3
	Yu, Chong; Nian, Yin; Chen, Huanhua; Liang, Shuwen; Sun, Mengyang; Pei, Yuehu; Wang, Haifeng
	2022
发表期刊	FRONTIERS IN CHEMISTRY
卷号	10 页码:950726
摘要	Two new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11S, 13R-(+)-phomacumarin A (1), three known pyranones (4-6), together with three known amide alkaloids fuscoatramides A-C (7-9), as well as 9S, 11R-(+)-ascosalitoxin (10) were isolated from the endophytic fungus Phoma sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive NMR spectroscopic and HRESIMS data and by comparing the information with literature data. In addition, all compounds were tested for their cytotoxicity activity against human tumor cell lines, and the results showed that new compounds 1-3 showed moderate inhibitory activity against the HL-60 cell line with IC50 values of 31.02, 34.62, and 27.90 mu M, respectively.
关键词	secondary metabolites plant endophytic fungus Phoma sp pyranone derivatives HL-60 inhibition
DOI	10.3389/fchem.2022.950726
收录类别	SCI
WOS记录号	WOS:000829663900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75655
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yu, Chong,Nian, Yin,Chen, Huanhua,et al. Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3[J]. FRONTIERS IN CHEMISTRY,2022,10:950726.
APA	Yu, Chong.,Nian, Yin.,Chen, Huanhua.,Liang, Shuwen.,Sun, Mengyang.,...&Wang, Haifeng.(2022).Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3.FRONTIERS IN CHEMISTRY,10,950726.
MLA	Yu, Chong,et al."Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3".FRONTIERS IN CHEMISTRY 10(2022):950726.

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